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Prevalence and predictive factors of osteoporosis in Thai systemic sclerosis
- Source :
- Scientific Reports, Scientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
- Publication Year :
- 2021
-
Abstract
- Systemic sclerosis (SSc) is recognized as a chronic inflammatory disease and several SSc-associated factors may increase the risk of osteoporosis and its related fractures. To determine the prevalence and predictive factors of osteoporosis in Thai SSc, a cross-sectional study was designed in adult SSc patients at Scleroderma clinic, Khon Kaen University Hospital. The prevalence of osteoporosis with the 95% confidence interval (CI) were determined and the odds ratio (OR) with 95%CI were assessed the clinical association with osteoporosis. A total of 205 SSc patients were recruited with the female to male ratio of 2.7:1. The majority of cases were diffuse SSc subset (83.4%) with a disease duration 2) and menopause were associated with osteoporosis at both the LS and FN. Using multivariate analysis, low BMI and menopause were associated with osteoporosis at LS (OR 7.78 and 5.32, respectively), while low BMI was also associated with osteoporosis at LS in pre-menopausal women. In conclusion, the prevalence of osteoporosis in Thai SSc was 29.3%. Osteoporosis at the LS is more common than FN in both men and women. Low BMI was associated with osteoporosis in overall SSc and pre-menopausal women, while only menopause was associated with osteoporosis at the FN.
- Subjects :
- Adult
Male
medicine.medical_specialty
Multivariate analysis
Cross-sectional study
Science
Osteoporosis
Age adjustment
Article
03 medical and health sciences
0302 clinical medicine
Internal medicine
Prevalence
Medicine
Humans
030212 general & internal medicine
skin and connective tissue diseases
Femoral neck
Aged
030203 arthritis & rheumatology
Aged, 80 and over
Multidisciplinary
Scleroderma, Systemic
integumentary system
business.industry
Femur Neck
Lumbosacral Region
Odds ratio
Middle Aged
medicine.disease
Thailand
Confidence interval
Menopause
medicine.anatomical_structure
Cross-Sectional Studies
Systemic sclerosis
Female
business
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific reports
- Accession number :
- edsair.doi.dedup.....cd11174bc96e7773cecd172f84d27e30