Back to Search
Start Over
Inflammatory and fibroblastic effects of azithromycin on cyclosporine-induced gingival overgrowth in renal transplanted patients with and without scaling: A randomized clinical trial
- Source :
- Journal of Oral Biosciences. 62:175-181
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Background: This study aimed to evaluate the effect of azithromycin (AZM) on the inflammatory and fibroblastic part of cyclosporine A (CsA)-induced gingival overgrowth (GO) in renal transplanted patients. Methods: In this randomized clinical trial, subjects with GO receiving CsA were randomly divided into two groups: those receiving 5-day AZM only (n = 12; group 1) and those receiving scaling and prescribed AZM after 2 months (n = 12; group 2). Both groups were evaluated for several indices (gingival hyperplastic index, plaque and bleeding index, clinical crown length) at the first visit and the 4th and 8th week in group 1, and at the first visit and the 4th, 8th, 12th, and 16th week in group 2. Results: The sample included 24 individuals. The mean (SD) age of participants was 30.81 (11.13) and 34.80 (9.33) years in group 1 and 2, respectively. Based on ANCOVA, the changes in the hyperplastic index (GHI) and apico-coronal dimension (ACD) of it were statistically significant in professional scaling accompanied by AZM group (P = 0.012 and 0.031, respectively). However, no significant change was observed in mean indices after prescribing AZM in 5-day AZM regimen group (P = 0.664 and 0.882, respectively). According to one-way ANOVA, we found a statistically significant correlation in GHI, ACD, bleeding index (BI), and plaque index (PI) accounting for P = 0.012, 0.003, 0.002, and
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Plaque index
Medicine (miscellaneous)
Azithromycin
Gastroenterology
General Biochemistry, Genetics and Molecular Biology
Gum inflammation
law.invention
03 medical and health sciences
0302 clinical medicine
Randomized controlled trial
law
Internal medicine
medicine
Humans
General Dentistry
Gingival Overgrowth
business.industry
030206 dentistry
Kidney Transplantation
Regimen
030104 developmental biology
Cyclosporine
Crown length
Analysis of variance
business
Immunosuppressive Agents
medicine.drug
Subjects
Details
- ISSN :
- 13490079
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Journal of Oral Biosciences
- Accession number :
- edsair.doi.dedup.....cd2c44514084652e53ff655ae363349b