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Relationship of Liver X Receptors α and Endoglin Levels in Serum and Placenta with Preeclampsia

Authors :
Jing Wang
Li-xin Shang
Hong-yan Wu
Xing Dong
Xin Wang
Xue-jun Zhang
Nan Wu
Source :
PLoS ONE, Vol 11, Iss 10, p e0163742 (2016), PLoS ONE
Publication Year :
2016
Publisher :
Public Library of Science (PLoS), 2016.

Abstract

Background Liver X receptor alpha (LXRα) and endoglin have been postulated to play roles in trophoblast invasion and lipid metabolic disturbances. However, the relationship between LXRα and endoglin levels in serum and placenta of patients with preeclampsia remains poorly understood. The objective of this study was to identify correlations between LXRα, endoglin and preeclampsia and provide new feasible methods of clinical prediction and treatment for preeclampsia. Methods We enrolled 45 patients with preeclampsia (24 with moderate preeclampsia and 21 with severe preeclampsia) and 15 normal pregnant women (control group) who were admitted to the Department of Obstetrics of the General Hospital of Beijing Command between October 2012 and July 2013 in this study. Serum and placental LXRα and endoglin levels were analyzed by enzyme-linked immunosorbent assay, real-time quantitative PCR, tissue microarray and immunohistochemistry. Results Serum and placental LXRα and endoglin levels were significantly higher in patients with preeclampsia than those in control group (P

Details

ISSN :
19326203
Volume :
11
Database :
OpenAIRE
Journal :
PLOS ONE
Accession number :
edsair.doi.dedup.....cd2edbf53c9716492f99fb175f72def9
Full Text :
https://doi.org/10.1371/journal.pone.0163742