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Particle-based platforms for malaria vaccines
- Source :
- Vaccine. (52):7518-7524
- Publisher :
- Elsevier Ltd. Published by Elsevier Ltd.
-
Abstract
- Recombinant subunit vaccines in general are poor immunogens likely due to the small size of peptides and proteins, combined with the lack or reduced presentation of repetitive motifs and missing complementary signal(s) for optimal triggering of the immune response. Therefore, recombinant subunit vaccines require enhancement by vaccine delivery vehicles in order to attain adequate protective immunity. Particle-based delivery platforms, including particulate antigens and particulate adjuvants, are promising delivery vehicles for modifying the way in which immunogens are presented to both the innate and adaptive immune systems. These particle delivery platforms can also co-deliver non-specific immunostimodulators as additional adjuvants. This paper reviews efforts and advances of the Particle-based delivery platforms in development of vaccines against malaria, a disease that claims over 600,000 lives per year, most of them are children under 5 years of age in sub-Sahara Africa.
- Subjects :
- Protective immunity
medicine.medical_treatment
Particle
Antigens, Protozoan
Biology
Article
Immune system
Adjuvants, Immunologic
Antigen
Immunology and Microbiology(all)
Malaria Vaccines
medicine
Humans
Subunit vaccines
Vaccines, Virus-Like Particle
Adjuvant
General Veterinary
General Immunology and Microbiology
Public Health, Environmental and Occupational Health
Vaccine delivery
medicine.disease
veterinary(all)
Malaria
Infectious Diseases
Vaccines, Subunit
Immunology
Nanoparticles
Molecular Medicine
Vaccine
Delivery
Subjects
Details
- Language :
- English
- ISSN :
- 0264410X
- Issue :
- 52
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....cd6624d9d7f11a164398a2c8f40dfa3c
- Full Text :
- https://doi.org/10.1016/j.vaccine.2015.09.097