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Piperlongumine attenuates collagen-induced arthritis via expansion of myeloid-derived suppressor cells and inhibition of the activation of fibroblast-like synoviocytes
- Source :
- Molecular medicine reports. 11(4)
- Publication Year :
- 2014
-
Abstract
- Piperlonguminine (PL), a key compound from the Piper longum fruit, is known to exhibit anti‑tumor and anti‑inflammatory activities. However, little is known about its effects on collagen‑induced arthritis (CIA). Fibroblast‑like synoviocytes (FLS) have a pivotal role in the development of rheumatoid arthritis (RA). Myeloid‑derived suppressor cells (MDSCs) are able to suppress T cell responses and have important roles in the regulation of autoimmune arthritis. The current study investigated whether PL alters the progression of RA. It was determined that PL reduces the arthritis score and histopathologic lesions in a mouse model of CIA. PL also reduces the expression levels of serum anti‑collagen II antibodies (anti‑CⅡ), tumor necrosis factor‑α (TNF‑α), interleukin (IL)‑1β, IL‑23 and IL‑17 in CIA mice. In draining lymph nodes (DLNs), MDSCs were significantly expanded, however, the number of Th17 cells was markedly decreased by PL treatment. Additionally, PL reduced secretion of IL‑1β, IL‑23 and IL‑17 by TNF‑α‑stimulated human RA FLS. PL significantly inhibited the migration and invasion of TNF‑α‑stimulated human RA FLS. These results indicate that PL may be a candidate therapeutic agent for the treatment of RA, via the expansion of MDSCs and the inhibition of the Th17 response and activation of FLS.
- Subjects :
- musculoskeletal diseases
Male
Cancer Research
T cell
Arthritis
Biochemistry
Piperlonguminine
Antibodies
Arthritis, Rheumatoid
chemistry.chemical_compound
Mice
Cell Movement
Genetics
Medicine
Animals
Myeloid Cells
Lymphocyte Count
Fibroblast
Molecular Biology
Collagen Type II
Piperlongumine
business.industry
Synovial Membrane
Interleukin
Dioxolanes
Fibroblasts
medicine.disease
Arthritis, Experimental
Disease Models, Animal
medicine.anatomical_structure
Oncology
chemistry
Immunology
Cancer research
Myeloid-derived Suppressor Cell
Molecular Medicine
Cytokines
Th17 Cells
Tumor necrosis factor alpha
Cattle
Female
Inflammation Mediators
business
Subjects
Details
- ISSN :
- 17913004
- Volume :
- 11
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Molecular medicine reports
- Accession number :
- edsair.doi.dedup.....cd9edd20ca11fbdefcf11139bba41d15