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Glycocalyx-targeted therapy ameliorates age-related arterial dysfunction
- Source :
- Geroscience. Springer International Publishing
- Publication Year :
- 2023
-
Abstract
- Advanced age is accompanied by arterial dysfunction, as well as a diminished glycocalyx, which may be linked to reduced high molecular weight-hyaluronan (HMW-HA) synthesis. However, the impact of glycocalyx deterioration in age-related arterial dysfunction is unknown. We sought to determine if manipulations in glycocalyx properties would alter arterial function. Tamoxifen-induced hyaluronan synthase 2 (Has2) reduction was used to decrease glycocalyx properties. Three weeks post-tamoxifen treatment, glycocalyx thickness was lower in Has2 knockout compared to wild-type mice (P0.05). Has2 reduction phenocopies age-related arterial dysfunction, while 10 weeks of glycocalyx-targeted therapy that restores the glycocalyx also ameliorates age-related arterial dysfunction. These findings suggest that the glycocalyx may be a viable therapeutic target to ameliorate age-related arterial dysfunction.
Details
- Language :
- English
- ISSN :
- 25092715
- Database :
- OpenAIRE
- Journal :
- Geroscience
- Accession number :
- edsair.doi.dedup.....cdbb28c954786fd713d5e210042d0cae