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Assessment of Promising Protein Markers for Vulva Cancer
- Source :
- International journal of gynecological cancer, 19(4), 756-760. Wolters Kluwer Health
- Publication Year :
- 2009
-
Abstract
- Objectives: To validate the results of a previous study with the tissue microarray technology showing that cyclooxygenase 2 (COX-2) overexpression and absent caspase 3 expression are associated with poor disease-specific survival in univariate analysis. Methods: The study group comprised 80 consecutive patients with vulva cancer treated in the period from 1999 to 2003 in a university hospital. A tissue microarray with 3 tumor tissue cores per patient was constructed and stained with antibodies against COX-2, caspase 3, epidermal growth factor receptor, p16(INK4), cyclin D1, and Ki-67. The impact of the expression of these protein markers and selected clinicopathologic variables on disease-specific as well as disease-free survival was measured. Cox proportional hazard model was used for both univariate and multivariate analyses. Results: In multivariate analysis, lymph node metastases and strong COX-2 expression were related to disease-free (hazard ratio [HR], 8.33, 95% confidence interval [CI], 2.97-23.36; P
- Subjects :
- Oncology
Pathology
medicine.medical_specialty
Caspase 3
Disease-Free Survival
Internal medicine
medicine
Biomarkers, Tumor
Humans
Epidermal growth factor receptor
Lymph node
Univariate analysis
Tissue microarray
biology
Vulvar Neoplasms
Proportional hazards model
business.industry
Hazard ratio
Obstetrics and Gynecology
Cancer
Reproducibility of Results
medicine.disease
Microarray Analysis
Immunohistochemistry
ErbB Receptors
medicine.anatomical_structure
Cyclooxygenase 2
biology.protein
Carcinoma, Squamous Cell
Female
business
Subjects
Details
- Language :
- English
- ISSN :
- 1048891X
- Database :
- OpenAIRE
- Journal :
- International journal of gynecological cancer, 19(4), 756-760. Wolters Kluwer Health
- Accession number :
- edsair.doi.dedup.....cdc2133badfc851f141697cb1c603bbd