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Impact of EGFR mutations and KRAS amino acid substitution on the response to radiotherapy for brain metastasis of non-small-cell lung cancer
- Publication Year :
- 2015
- Publisher :
- Future Medicine, 2015.
-
Abstract
- Background: Our study aimed to evaluate response rate (RR) to brain metastasis radiotherapy (RT), depending on the genomic status of non-small-cell lung cancer. Material & methods: We retrospectively reviewed 1971 non-small-cell lung cancer files of patients with EGFR and KRAS testing and focused on 157 patients who had undergone RT for brain metastasis. Results: A total of 16 patients (10.2%) harbored EGFR mutations (mEGFR) and 45 patients (28.7%) KRAS (mKRAS). In univariate analysis, RR was significantly higher for mEGFR compared with wild-type EGFR/KRAS (odds ratio [OR]: 4.96; p = 0.05) or mKRAS (OR: 1.81; p = 0.03). In multivariate analysis, KRAS G12V or G12C status was associated with both poor RR (OR: 0.1; p < 0.0001) and overall survival (OR: 3.41; p < 0.0001). Conclusion: mEGFR are associated with higher RR to brain RT than wild-type EGFR/RAS or mKRAS.
- Subjects :
- Adult
Male
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
Kaplan-Meier Estimate
medicine.disease_cause
Sciences du Vivant [q-bio]/Cancer
Polymorphism, Single Nucleotide
Radiation Tolerance
Disease-Free Survival
Proto-Oncogene Proteins p21(ras)
03 medical and health sciences
0302 clinical medicine
Carcinoma, Non-Small-Cell Lung
Internal medicine
medicine
Humans
Lung cancer
Genetic Association Studies
Aged
Aged, 80 and over
Mutation
Univariate analysis
Brain Neoplasms
business.industry
General Medicine
Odds ratio
Middle Aged
medicine.disease
ErbB Receptors
Radiation therapy
030104 developmental biology
Amino Acid Substitution
030220 oncology & carcinogenesis
Female
KRAS
business
Brain metastasis
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....cdd643f1e6b64571da7877007934410b