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Electrocardiographic evolution in patients with hypertrophic cardiomyopathy who develop a left ventricular apical aneurysm
- Publication Year :
- 2015
- Publisher :
- Churchill Livingstone Inc., 2015.
-
Abstract
- Introduction Hypertrophic cardiomyopathy (HCM) patients with apical aneurysm have a largely unfavourable clinical course, and are often unrecognised because echocardiography is limited in the assessment of the left ventricular (LV) apex. The aim of this study is the identification of electrocardiographic (ECG) abnormalities associated with the development of apical aneurysm in HCM patients. Materials and methods Electrocardiographic features were assessed in 14 HCM patients who had a good-quality baseline ECG recorded before and after the diagnosis of apical aneurysm. Results During follow-up (8.8±7.5years), the following ECG changes were observed: increase in QRS-complex duration (87±12ms to 118±34ms, p=0.006), QRS-complex fragmentation, decrease in QRS-complex amplitude (SV 1 +RV 5-6 , from 41±18mm to 26±11mm, p=0.015), ST-segment elevation in V 4 –V 6 (J-point in V 5 , from −0.9±1.3mm to +0.7±1.3, p=0.003), positivisation of negative T waves in V 3 -V 6 (T-wave depth in V 5 , from −3.4±6.6 to +3.1±4.1, p=0.005). Conclusions HCM patients who develop LV apical aneurysm exhibit distinctive ECG changes along with apical remodelling. Suggestive ECGs should lead the physician to study LV apex by nonstandard echocardiographic views, and perform MRI.
- Subjects :
- Adult
Male
medicine.medical_specialty
electrocardiography
Sensitivity and Specificity
Ventricular Dysfunction, Left
Internal medicine
T wave
medicine
apical aneurysm
hypertrophic cardiomyopathy
cardiology and cardiovascular medicine
Humans
In patient
Longitudinal Studies
cardiovascular diseases
Heart Aneurysm
Aged
Aged, 80 and over
Apical aneurysm
medicine.diagnostic_test
business.industry
Clinical course
Hypertrophic cardiomyopathy
Reproducibility of Results
Cardiomyopathy, Hypertrophic
Middle Aged
medicine.disease
Apex (geometry)
Disease Progression
cardiovascular system
Cardiology
Female
business
Electrocardiography
Follow-Up Studies
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....cde4828c60eb4d1f6ed15c58cf7246f4