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Physical activity compared to adiposity and risk of liver-related mortality: Results from two prospective, nationwide cohorts
- Source :
- J Hepatol
- Publication Year :
- 2019
-
Abstract
- BACKGROUND & AIMS: Obesity in adulthood has been associated with increased risk of liver-related mortality. Whether higher levels of physical activity counteract the excess risk conferred by obesity remains unknown. We simultaneously evaluated the long-term impact of physical activity and adiposity on liver-related mortality, within two nationwide populations. METHODS: We conducted a prospective cohort study of 77,238 women and 48,026 men, with detailed, validated assessments of weekly physical activity (metabolic equivalent task [MET]-hours]), adiposity (body mass index [BMI], waist circumference), and diet, alcohol use and clinical comorbidities, biennially from 1986 through 2012. Using Cox proportional hazards regression models, we calculated multivariable adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for liver-related mortality, including death from hepatocellular carcinoma (HCC) and other cirrhosis complications. RESULTS: Over 1,856,226 person-years, we recorded 295 liver-related deaths (108 HCC; 187 cirrhosis). Risk of liver-related mortality increased monotonically with higher BMI during adulthood (P(trend)3 hours/week could have prevented 25% of liver-related deaths (95%CI=0.12-0.38). CONCLUSIONS: In two prospective, nationwide cohorts, both excess adiposity and reduced PA were significant predictors of liver-related mortality. Achieving higher PA levels counteracted the excess liver-related risks associated with obesity.
- Subjects :
- 0301 basic medicine
Adult
Liver Cirrhosis
Male
medicine.medical_specialty
Waist
Carcinoma, Hepatocellular
Nurses
Comorbidity
Lower risk
Metabolic equivalent
Article
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
medicine
Humans
Obesity
Prospective Studies
Prospective cohort study
Exercise
Adiposity
Aged
Aged, 80 and over
Hepatology
business.industry
Hazard ratio
Liver Neoplasms
Absolute risk reduction
Middle Aged
medicine.disease
United States
030104 developmental biology
030211 gastroenterology & hepatology
Female
Waist Circumference
business
Body mass index
Follow-Up Studies
Subjects
Details
- ISSN :
- 16000641
- Volume :
- 72
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of hepatology
- Accession number :
- edsair.doi.dedup.....cdf3a599f054fe94d4c49b4b65774aad