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Modulation of phenotype and function of dendritic cells by a therapeutic synthetic killer peptide
Modulation of phenotype and function of dendritic cells by a therapeutic synthetic killer peptide
- Source :
- Journal of Leukocyte Biology. 79:40-45
- Publication Year :
- 2005
- Publisher :
- Oxford University Press (OUP), 2005.
-
Abstract
- The strong microbicidal effects of an engineered synthetic killer peptide (KP), which functionally mimics a fungal killer toxin, have been demonstrated extensively. β-glucan has been identified as a receptor for KP on fungal cell walls. Although the direct microbicidal and related therapeutic effects have been studied in depth, no information currently exists about the interaction of KP with immune cells. In this study, we exploited the possibility of KP binding to different murine immune cell populations. The results demonstrate that KP binds selectively to dendritic cells (DC) and to a lesser extent, to macrophages but not to lymphocytes and neutrophils; KP binding possibly occurs through major histocompatibility complex (MHC) class II, CD16/32, and cellular molecules recognized by anti-specific intercellular adhesion molecule-grabbing nonintegrin R1 antibodies; and KP modulates the expression of costimulatory and MHC molecules on DC and improves their capacity to induce lymphocyte proliferation. These findings provide evidence that this synthetic KP interacts selectively with DC and modulating their multiple functions, might also serve to improve the immune antimicrobial response.
- Subjects :
- Antifungal Agents
beta-Glucans
Immunology
Cell
Antimicrobial peptides
Lymphocyte proliferation
CD16
Major histocompatibility complex
Mice
Immune system
Leukocytes
medicine
Animals
Immunology and Allergy
Receptor
Cells, Cultured
Cell Proliferation
Immunity, Cellular
Mice, Inbred BALB C
biology
Receptors, IgG
Histocompatibility Antigens Class II
Dendritic Cells
Cell Biology
Cell biology
medicine.anatomical_structure
Mycoses
Biochemistry
biology.protein
Antibody
Oligopeptides
Subjects
Details
- ISSN :
- 19383673 and 07415400
- Volume :
- 79
- Database :
- OpenAIRE
- Journal :
- Journal of Leukocyte Biology
- Accession number :
- edsair.doi.dedup.....cdf86e1435015cb856b3762ea4921acf
- Full Text :
- https://doi.org/10.1189/jlb.0205113