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Factors predicting the recovery from acute kidney injury in children with primary nephrotic syndrome
- Source :
- Clinical and Experimental Nephrology. 25:1011-1017
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- The prognosis of acute kidney injury (AKI) varies in children with nephrotic syndrome (NS), data on factors predicting the recovery and recurrence of AKI in children with NS are limited. This study aimed to explore the possible factors predicting the recovery from and recurrence of AKI in children with primary NS. Children with primary NS complicated with AKI from 1993 to 2017 in a single centre were reviewed retrospectively. The clinical pictures and possible factors predicting the recovery from and recurrence of AKI in children with primary NS were investigated. Sixty-eight episodes of AKI in 59 children with NS were analysed: 88.2% of AKI recovered within 3 months, and 2.9% of AKI did not recover after 3 months. Survival analysis revealed that leucocyturia is significantly related to the AKI recovery time (P = 0.001), and children with leucocyturia [22 (4, 79) days] recovered significantly slower than did children without leucocyturia [12.0 (2, 39) days]. Renal tubular and interstitial injury were prominent in children with leucocyturia, and 11.9% of children with index AKI experienced the recurrence of AKI. Most episodes of AKI that occurred in children with NS recovered completely. Leucocyturia is a significant factor predicting the recovery time of AKI.
- Subjects :
- Male
Nephrology
medicine.medical_specialty
Nephrotic Syndrome
Time Factors
Adolescent
Leukocytosis
Physiology
030232 urology & nephrology
Urine
030204 cardiovascular system & hematology
urologic and male genital diseases
03 medical and health sciences
0302 clinical medicine
Recurrence
Renal Dialysis
Risk Factors
Physiology (medical)
Internal medicine
Leukocytes
medicine
Humans
Child
Survival analysis
Retrospective Studies
urogenital system
business.industry
Acute kidney injury
Recovery of Function
Acute Kidney Injury
Prognosis
medicine.disease
female genital diseases and pregnancy complications
Single centre
Kidney Tubules
Child, Preschool
Female
business
Nephrotic syndrome
Subjects
Details
- ISSN :
- 14377799 and 13421751
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Clinical and Experimental Nephrology
- Accession number :
- edsair.doi.dedup.....ce00d1f350cb721cdcdc3ce65dba808c