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Calcite Single Crystals as Hosts for Atomic-Scale Entrapment and Slow Release of Drugs

Authors :
Matteo Calvaresi
Pier Giuseppe Pelicci
Boaz Pokroy
Francesco Zerbetto
Giuseppe Falini
Giulia Magnabosco
Andrea Bottoni
M. Di Giosia
Iryna Polishchuk
Stefania Rapino
Eva Weber
Simona Fermani
Magnabosco, G.
Di Giosia, M.
Polishchuk, I.
Weber, E.
Fermani, S.
Bottoni, A.
Zerbetto, F.
Pelicci, P.G.
Pokroy, B.
Rapino, S.
Falini, G.
Calvaresi, M.
Source :
Advanced healthcare materials. 4(10)
Publication Year :
2015

Abstract

Doxorubicin (DOX)/CaCO3 single crystals act as pH responsive drug carrier. A biomimetic approach demonstrates that calcite single crystals are able, during their growth in the presence of doxorubicin, to entrap drug molecules inside their lattice along specific crystallographic directions. Alterations in lattice dimensions and microstructural parameters are determined by means of high-resolution synchrotron powder diffraction measurements. Confocal microscopy confirms that doxorubicin is uniformly embedded in the crystal and is not simply adsorbed on the crystal surface. A slow release of DOX was obtained preferentially in the proximity of the crystals, targeting cancer cells.

Details

ISSN :
21922659
Volume :
4
Issue :
10
Database :
OpenAIRE
Journal :
Advanced healthcare materials
Accession number :
edsair.doi.dedup.....ce02ecc6c6c127b8110856c536836beb