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Calcite Single Crystals as Hosts for Atomic-Scale Entrapment and Slow Release of Drugs
- Source :
- Advanced healthcare materials. 4(10)
- Publication Year :
- 2015
-
Abstract
- Doxorubicin (DOX)/CaCO3 single crystals act as pH responsive drug carrier. A biomimetic approach demonstrates that calcite single crystals are able, during their growth in the presence of doxorubicin, to entrap drug molecules inside their lattice along specific crystallographic directions. Alterations in lattice dimensions and microstructural parameters are determined by means of high-resolution synchrotron powder diffraction measurements. Confocal microscopy confirms that doxorubicin is uniformly embedded in the crystal and is not simply adsorbed on the crystal surface. A slow release of DOX was obtained preferentially in the proximity of the crystals, targeting cancer cells.
- Subjects :
- Materials science
high-resolution synchrotron powder diffraction
Cell Survival
Biomedical Engineering
Pharmaceutical Science
Nanotechnology
macromolecular substances
Atomic units
law.invention
Calcium Carbonate
Biomaterials
Crystal
Entrapment
chemistry.chemical_compound
Adsorption
Confocal microscopy
law
Cell Line, Tumor
polycyclic compounds
Molecule
Humans
drug carrier
Calcite
Drug Carriers
Microscopy, Confocal
intracrystalline
Crystallography
Calcium carbonate
chemistry
Doxorubicin
Microscopy, Electron, Scanning
Drug carrier
Crystallization
Subjects
Details
- ISSN :
- 21922659
- Volume :
- 4
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Advanced healthcare materials
- Accession number :
- edsair.doi.dedup.....ce02ecc6c6c127b8110856c536836beb