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Current trends and opportunities in targeting p21 activated kinase-1(PAK1) for therapeutic management of breast cancers
- Source :
- Gene. 760
- Publication Year :
- 2020
-
Abstract
- Breast cancer is the most frequently diagnosed cancer in women worldwide. Identifying reliable biomarkers and druggable molecular targets pose to be a significant quest in breast cancer research. p21-activated kinase 1 (PAK1) is a serine/threonine kinase that direct cell motility, cytoskeletal remodelling, and has been shown to function as a downstream regulator for various cancer signalling cascades that promote cell proliferation, apoptosis deregulation and hasten mitotic abnormalities, resulting in tumor formation and progression. The heterogeneity and acquired drug resistance are important factors that challenge the treatment of breast cancer. p21-activated kinase 1 signalling is crucial for activation of the Ras/RAF/MEK/ERK, PI3K/Akt/mTOR and Wnt signalling cascades which regulate cell survival, cell cycle progression, differentiation, and proliferation. A study involving proteogenomics analysis on breast cancer tissues showed the PAK1 as outlier kinase. In addition to this, few outlier molecules were identified specific to subtypes of breast cancer. A few substrates of PAK1 in breast cancer are already known. In this paper, we have discussed a similar approach called Kinase Interacting Substrate Screening (KISS) for the identification of novel oncogenic substrates of p21-activated kinase specific to subtypes of breast cancer. Such high throughput approaches are expected to accelerate the process of identifying novel drug targets and biomarkers.
- Subjects :
- 0301 basic medicine
MAPK/ERK pathway
Cell Survival
Apoptosis
Breast Neoplasms
Biology
03 medical and health sciences
0302 clinical medicine
PAK1
Breast cancer
Cell Line, Tumor
Genetics
medicine
Animals
Humans
Protein kinase B
PI3K/AKT/mTOR pathway
Cell Proliferation
Cell growth
Kinase
Cancer
General Medicine
medicine.disease
030104 developmental biology
p21-Activated Kinases
030220 oncology & carcinogenesis
Cancer research
Female
Signal Transduction
Subjects
Details
- ISSN :
- 18790038
- Volume :
- 760
- Database :
- OpenAIRE
- Journal :
- Gene
- Accession number :
- edsair.doi.dedup.....ce0fecab81b7f0dd685571269a4600c2