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Innate immune receptors, key actors in cardiovascular diseases
- Source :
- Digital.CSIC. Repositorio Institucional del CSIC, instname, JACC: Basic to Translational Science, Biblos-e Archivo. Repositorio Institucional de la UAM, Consejo Superior de Investigaciones Científicas (CSIC), Biblos-e Archivo: Repositorio Institucional de la UAM, Universidad Autónoma de Madrid
- Publication Year :
- 2020
- Publisher :
- Elsevier, 2020.
-
Abstract
- Central Illustration<br />Highlights • The present review recapitulates relevant findings related to the role of the receptors of the innate immune system (TLRs and NLRs) in the progression of the most prevalent CVDs. • TLRs and NLRs play a key role in the progression of atherosclerosis, acute myocardial infarction or heart failure. • The development of new specific strategies to impair exacerbated TLR and NLR activation in CVDs are strong candidates for therapy and opens a new research field.<br />Summary Cardiovascular diseases (CVDs) are the leading cause of death in the industrialized world. Most CVDs are associated with increased inflammation that arises mainly from innate immune system activation related to cardiac damage. Sustained activation of the innate immune system frequently results in maladaptive inflammatory responses that promote cardiovascular dysfunction and remodeling. Much research has focused on determining whether some mediators of the innate immune system are potential targets for CVD therapy. The innate immune system has specific receptors—termed pattern recognition receptors (PRRs)—that not only recognize pathogen-associated molecular patterns, but also sense danger-associated molecular signals. Activation of PRRs triggers the inflammatory response in different physiological systems, including the cardiovascular system. The classic PRRs, toll-like receptors (TLRs), and the more recently discovered nucleotide-binding oligomerization domain-like receptors (NLRs), have been recently proposed as key partners in the progression of several CVDs (e.g., atherosclerosis and heart failure). The present review discusses the key findings related to the involvement of TLRs and NLRs in the progression of several vascular and cardiac diseases, with a focus on whether some NLR subtypes (nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain-containing receptor 3 and nucleotide-binding oligomerization domain-containing protein 1) can be candidates for the development of new therapeutic strategies for several CVDs.
- Subjects :
- 0301 basic medicine
NF-κB, nuclear factor κ-light-chain-enhancer of activated B cells
innate immune system
Nucleotide-binding oligomerization domain-like receptors
030204 cardiovascular system & hematology
Pyrin domain
STATE-OF-THE-ART REVIEW
HF, heart failure
0302 clinical medicine
cardiovascular disease
NOD1
Medicine
Receptor
Innate immune system
Pattern recognition receptor
Cardiovascular diseases
CARD, caspase activation and recruitment domain
medicine.symptom
Cardiology and Cardiovascular Medicine
DAP, D-glutamyl-meso-diaminopimelic acid
PAMP, pathogen-associated molecular pattern
nucleotide-binding oligomerization domain-like receptors
Medicina
Inflammatory response
NLR, nucleotide-binding oligomerization domain-like receptors
I/R, ischemia/reperfusion
Inflammation
Leucine-rich repeat
CVD, cardiovascular disease
ER, endoplasmic reticulum
03 medical and health sciences
ROS, reactive oxygen species
NLRP3
NOD, Nucleotide-binding oligomerization domain-containing protein
DAMPs, danger-associated molecular patterns
Ca2+, calcium ion
TLR, toll-like receptor
business.industry
SR, sarcoplasmic reticulum
AMI, acute myocardial infarction
IL, interleukin
Toll-like receptors
030104 developmental biology
toll-like receptors
Immunology
NLRP, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain-containing receptor
business
MAPK, mitogen-activated protein kinase
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Digital.CSIC. Repositorio Institucional del CSIC, instname, JACC: Basic to Translational Science, Biblos-e Archivo. Repositorio Institucional de la UAM, Consejo Superior de Investigaciones Científicas (CSIC), Biblos-e Archivo: Repositorio Institucional de la UAM, Universidad Autónoma de Madrid
- Accession number :
- edsair.doi.dedup.....ce1d6d393016f9f807d1f1f67e4a58c1