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Conservation of Atypical Allostery in C. elegans UDP-Glucose Dehydrogenase

Authors :
Trevor M. Talmadge
Tiffany N. Hicks Sirmans
Weston E. McDonald
Nicholas D. Keul
Zachary A. Wood
Rahil Taujale
Nathaniel R. Beattie
Natarajan Kannan
Source :
ACS Omega, Vol 4, Iss 15, Pp 16318-16329 (2019)
Publication Year :
2019
Publisher :
American Chemical Society (ACS), 2019.

Abstract

Human UDP-glucose dehydrogenase (hUGDH) oxidizes uridine diphosphate (UDP)-glucose to UDP-glucuronic acid, an essential substrate in the phase II metabolism of drugs. The activity of hUGDH is contr...

Subjects

Subjects :
Phase II metabolism
0303 health sciences
Chemistry
General Chemical Engineering
030302 biochemistry & molecular biology
Allosteric regulation
Substrate (chemistry)
Dehydrogenase
General Chemistry
carbohydrates (lipids)
03 medical and health sciences
Uridine diphosphate
chemistry.chemical_compound
Biochemistry
Udp glucose dehydrogenase
QD1-999
030304 developmental biology

Details

ISSN :
24701343
Volume :
4
Database :
OpenAIRE
Journal :
ACS Omega
Accession number :
edsair.doi.dedup.....ce2a42d39f5c0223e99bb49a471b365f

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