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Association of family history and survival in patients with colorectal cancer: a pooled analysis of eight epidemiologic studies
- Source :
- Cancer Medicine
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- A family history of colorectal cancer (CRC) in first‐degree relatives (FDRs) increases the risk of CRC. However, the influence of family history on survival among CRC patients remains unclear. We conducted a pooled analysis of survival in 5010 incident CRC cases. Cox proportional hazards models were used to estimate the association of family history with overall survival (OS) and CRC‐specific survival (CSS). We also assessed the impact of the number of affected FDRs and age at CRC diagnosis in the affected FDRs on survival. Among CRC cases, 819 (16%) patients reported a family history of CRC. There were 1580 total deaths over a median follow‐up of 4.6 years, of which 1046 (66%) deaths were due to CRC. Having a family history of CRC was not associated with OS [hazard ratio (HR), 1.03; 95% confidence interval (CI), 0.89–1.19] or CSS (HR, 1.13; 95% CI, 0.95–1.36)]. There were no associations between the number of affected relatives or age at CRC diagnosis of the affected relative with survival (all P trend > 0.05). However, a family history of CRC did confer worse CSS in patients diagnosed with distal colon cancer (HR, 1.45, 95% CI, 1.03–2.04). A family history of CRC was generally not associated with survival after CRC diagnosis. However, having a family history of CRC was associated with worse CRC prognosis in individuals with distal colon cancer, suggesting a possible genetic predisposition with distinct pathogenic mechanism that may lead to worse survival in this group.
- Subjects :
- Adult
Male
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Colorectal cancer
survival
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Genetic predisposition
Humans
Medicine
Family
Genetic Predisposition to Disease
Radiology, Nuclear Medicine and imaging
First-degree relatives
Family history
Medical History Taking
neoplasms
Original Research
Aged
Proportional Hazards Models
family history
business.industry
Proportional hazards model
first‐degree relative
Hazard ratio
Cancer
Middle Aged
medicine.disease
mortality
digestive system diseases
Confidence interval
3. Good health
Epidemiologic Studies
030104 developmental biology
Case-Control Studies
030220 oncology & carcinogenesis
Female
Colorectal Neoplasms
business
Cancer Prevention
Subjects
Details
- ISSN :
- 20457634
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Cancer Medicine
- Accession number :
- edsair.doi.dedup.....ce35434485dfa9478668af0b464e38a6