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The AlkB Family of Fe (II)/Alpha-Ketoglutarate-Dependent Dioxygenases Modulates Embryogenesis through Epigenetic Regulation
- Source :
- Current Stem Cell Research & Therapy. 13
- Publication Year :
- 2018
- Publisher :
- Bentham Science Publishers Ltd., 2018.
-
Abstract
- Background The study of epigenetic regulation has made substantial progress in recent years. The AlkB family in E. coli was identified as a type of DNA repair enzyme that removes alkyl adducts from nucleobases. Recently, nine mammalian homologs, ALKBH1-9, have been successfully identified and defined as diverse demethylases. ALKBH1, ALKBH5, ALKBH8 and ALKBH9 act as RNA demethylases, while ALKBH2-3 and ALKBH7 correct methyl and etheno adducts in DNA. Moreover, ALKBH4 focuses primarily on actin. Disorders of AlkB family level in mammals induce many types of diseases. Objective In this review, we will elaborate on the structure and biological function of the members of the AlkB family. We will also focus on the latest progress of the research on the mammalian AlkB family, particularly on new breakthroughs, and present the relevant disorders or diseases induced by an abnormal level of the AlkB family. Conclusion The AlkB family plays a crucial role in embryogenesis and differentiation. The aberrant level of the AlkB family leads to many types of diseases. The members of the AlkB family may serve as potential cancer markers and possible therapeutic targets in the future.
- Subjects :
- 0301 basic medicine
DNA repair
AlkB
Embryonic Development
Medicine (miscellaneous)
Biology
Epigenesis, Genetic
Mixed Function Oxygenases
Mitochondrial Proteins
03 medical and health sciences
chemistry.chemical_compound
Alpha ketoglutarate
Gene expression
Escherichia coli
Animals
Humans
Epigenetics
Genetics
AlkB Enzymes
RNA
General Medicine
DNA Methylation
Phenotype
030104 developmental biology
chemistry
biology.protein
DNA
Subjects
Details
- ISSN :
- 1574888X
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Current Stem Cell Research & Therapy
- Accession number :
- edsair.doi.dedup.....ce586e1342524ca8919a969d983b4539