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Effect of obesity and metabolic syndrome on plasma oxysterols and fatty acids in human
- Source :
- Steroids, Steroids, Elsevier, 2015, 99 (Part B), pp.287-292. ⟨10.1016/j.steroids.2015.03.019⟩
- Publication Year :
- 2015
-
Abstract
- International audience; Background: Obesity and the related entity metabolic syndrome are characterized by altered lipid metabolism and associated with increased morbidity risk for cardiovascular disease and cancer. Oxysterols belong to a large family of cholesterol-derived molecules known to play crucial role in many signaling pathways underlying several diseases. Little is known on the potential effect of obesity and metabolic syndrome on oxysterols in human. Objectives: In this work, we questioned whether circulating oxysterols might be significantly altered in obese patients and in patients with metabolic syndrome. We also tested the potential correlation between circulating oxysterols and fatty acids. Methods: 60 obese patients and 75 patients with metabolic syndrome were enrolled in the study along with 210 age- and sex-matched healthy subjects, used as control group. Plasma oxysterols were analyzed by isotope dilution GC/MS, and plasma fatty acids profiling was assessed by gas chromatography coupled with flame ionization detection. Results: We found considerable differences in oxysterols profiling in the two disease groups that were gender-related. Compared to controls, males showed significant differences only in 4 alpha- and 4 beta-hydroxycholesterol levels in obese and metabolic syndrome patients. In contrast, females showed consistent differences in 7-oxocholesterol, 4 alpha-hydroxycholesterol, 25-hydroxycholesterol and triol. Concerning fatty acids, we found minor differences in the levels of these variables in males of the three groups. Significant changes were observed in plasma fatty acid profile of female patients with obesity or metabolic syndrome. We found significant correlations between various oxysterols and fatty acids. In particular, 4 beta-hydroxycho1esterol, which is reduced in obesity and metabolic syndrome, correlated with a number of saturated and mono-unsaturated fatty acids that are end-products of de novo lipogenesis. Conclusions: Our data provide the first evidence that obesity and metabolic syndrome are associated with major, gender-specific, changes in circulating oxysterols and fatty acids. These findings suggest a metabolic link between oxysterols and fatty acids, and that oxysterols may contribute to the epidemic diseases associated with obesity and metabolic syndrome in female.
- Subjects :
- Adult
Male
medicine.medical_specialty
[SDV]Life Sciences [q-bio]
Clinical Biochemistry
Disease
Biology
Biochemistry
Endocrinology
Diabetes mellitus
Internal medicine
polycyclic compounds
medicine
Cluster Analysis
Humans
Obesity
Oxysterols
Fatty acids
Metabolic syndrome
Diabetes
Lipid metabolism
Molecular Biology
Demography
2. Zero hunger
Pharmacology
chemistry.chemical_classification
Metabolic Syndrome
Organic Chemistry
Fatty Acids
Fatty acid
Middle Aged
medicine.disease
3. Good health
Sterols
Cholesterol
chemistry
Lipogenesis
lipids (amino acids, peptides, and proteins)
Female
Signal transduction
Oxidation-Reduction
Subjects
Details
- ISSN :
- 18785867 and 0039128X
- Volume :
- 99
- Database :
- OpenAIRE
- Journal :
- Steroids
- Accession number :
- edsair.doi.dedup.....ce5b436a55ce5a38820ca42ca69cc213