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Highly Hydrophilic Luminescent Magnetic Mesoporous Carbon Nanospheres for Controlled Release of Anticancer Drug and Multimodal Imaging
- Source :
- Langmuir : the ACS journal of surfaces and colloids. 32(6)
- Publication Year :
- 2016
-
Abstract
- Judicious combination of fluorescence and magnetic properties along with ample drug loading capacity and control release property remains a key challenge in the design of nanotheranostic agents. This paper reports the synthesis of highly hydrophilic optically traceable mesoporous carbon nanospheres which can sustain payloads of the anticancer drug doxorubicin and T2 contrast agent such as cobalt ferrite nanoparticles. The luminescent magnetic hybrid system has been prepared on a mesoporous silica template using a resorcinol-formaldehyde precursor. The mesoporous matrix shows controlled release of the aromatic drug doxorubicin due to disruption of supramolecular π-π interaction at acidic pH. The particles show MR contrast behavior by affecting the proton relaxation with transverse relaxivity (r2) 380 mM(-1) S(-1). The multicolored emission and upconversion luminescence property of our sample are advantageous in bioimaging. In vitro cell experiments shows that the hybrid nanoparticles are endocyted by the tumor cells through passive targeting. The pH-responsive release of doxorubicin presents chemotherapeutic inhibition of cell growth through induction of apoptosis.
- Subjects :
- Luminescence
Ultraviolet Rays
Supramolecular chemistry
Nanoparticle
Nanotechnology
Antineoplastic Agents
02 engineering and technology
010402 general chemistry
01 natural sciences
Ferric Compounds
Theranostic Nanomedicine
Formaldehyde
Electrochemistry
medicine
Humans
General Materials Science
Doxorubicin
Spectroscopy
Drug Carriers
Chemistry
Magnetic Phenomena
Optical Imaging
Surfaces and Interfaces
Cobalt
Resorcinols
Mesoporous silica
Hydrogen-Ion Concentration
021001 nanoscience & nanotechnology
Condensed Matter Physics
Controlled release
Carbon
0104 chemical sciences
Drug Liberation
0210 nano-technology
Mesoporous material
Drug carrier
Nanospheres
medicine.drug
HeLa Cells
Subjects
Details
- ISSN :
- 15205827
- Volume :
- 32
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Langmuir : the ACS journal of surfaces and colloids
- Accession number :
- edsair.doi.dedup.....ce62e38c92467a71b1ab00e054065d0f