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Th17 Response of Borderline-Lepromatous Leprosy Inhibits Rash Manifestation of Dapsone Hypersensitivity Syndrome: Case Report
- Source :
- Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual), Universidade de São Paulo (USP), instacron:USP
- Publication Year :
- 2017
-
Abstract
- Background Dapsone hypersensitivity syndrome (DHS) is a rare, but potentially life-threatening reaction to dapsone. Objective Evaluation of immunological factors involved in the sparing of borderline-lepromatous (BL) leprosy patches by the severe exanthema related to DHS. Methods The authors describe a 19-year-old man with borderline-lepromatous leprosy with a recent diffuse rash, sparing only the hypochromic patches of leprosy, generalized lymphadenopathy, hepatomegaly, and jaundice 25 days after the start of multibacillary multidrug therapy. Results Laboratory testing was remarkable for leukocytosis with eosinophilia, atypical lymphocytosis, and elevated liver and canalicular enzymes. Immunohistopathology of the rash showed stronger expression of Th1 cytokines (IL1β, TNFα, IFNγ, and iNOS), and limited expression of IL17, TGFb, IL4, and IL10. Whereas the hypochromic leprosy patches showed high expression of inflammatory cytokines IL1β, TNFα, IFNγ, iNOS, and TGFβ (Th1), and presented strong expression of IL17 and TGFβ with no IL4 and IL10 expression, by the inflammatory infiltrate, characterizing a participation of Th17 response. Conclusion Th17 response, coupled with the presence of subepidermal collagen band, seems to be directly related to the absence of DHS rash in these hypochromic leprosy patches.
- Subjects :
- Male
030231 tropical medicine
Leprostatic Agents
Dermatology
Dapsone
Pathology and Forensic Medicine
Proinflammatory cytokine
030207 dermatology & venereal diseases
03 medical and health sciences
Young Adult
0302 clinical medicine
medicine
Eosinophilia
Humans
Leprosy, Borderline
Leukocytosis
business.industry
Borderline lepromatous leprosy
General Medicine
medicine.disease
Rash
INTERLEUCINAS
Immunology
Drug Hypersensitivity Syndrome
Th17 Cells
Leprosy
medicine.symptom
business
Generalized lymphadenopathy
medicine.drug
Subjects
Details
- ISSN :
- 15330311
- Volume :
- 40
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- The American Journal of dermatopathology
- Accession number :
- edsair.doi.dedup.....ce80b2a3577609783095833fd8c60124