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Genetic liability for schizophrenia predicts risk of immune disorders
- Source :
- Schizophrenia Research, 159(2-3), 347-52. Elsevier, Stringer, S, Kahn, R S, de Witte, L D, Ophoff, R A & Derks, E M 2014, ' Genetic liability for schizophrenia predicts risk of immune disorders ', Schizophrenia Research, vol. 159, no. 2-3, pp. 347-52 . https://doi.org/10.1016/j.schres.2014.09.004, Schizophrenia research, 159(2-3), 347-352. Elsevier
- Publication Year :
- 2014
-
Abstract
- BACKGROUND: Schizophrenia patients and their parents have an increased risk of immune disorders compared to population controls and their parents. This may be explained by genetic overlap in the pathogenesis of both types of disorders. The purpose of this study was to investigate the genetic overlap between schizophrenia and three immune disorders and to compare with the overlap between schizophrenia and two disorders not primarily characterized by immune dysregulation: bipolar disorder and type 2 diabetes.METHODS: We performed a polygenic risk score analysis using results from the schizophrenia Psychiatric GWAS consortium (PGC) (8922 cases and 9528 controls) and five Wellcome Trust Case Control Consortium (WTCCC) case samples as target cases: bipolar disorder (n=1998), type 1 diabetes (n=2000), Crohn's diseases (n=2005), rheumatoid arthritis (n=1999), and type 2 diabetes (n=1999). The WTCCC British Birth Cohort and National Blood Service samples (n=3004) were used as target controls. Additionally, we tested whether schizophrenia polygenic risk scores significantly differed between patients with immune disorder, bipolar disorder, and type 2 diabetes respectively.RESULTS: Polygenic risk scores for schizophrenia significantly predicted disease status in all three immune disorder samples (Nagelkerke-R(2) 1.1%-1.3%; pCONCLUSIONS: Our results suggest that genetic factors are shared between schizophrenia and immune disorders. This contributes to an accumulating body of evidence that immune processes may play a role in the etiology of schizophrenia.
- Subjects :
- Male
Major histocompatibility complex
Genetic overlap
Type 2 diabetes
Review
medicine.disease_cause
Risk Factors
Medicine
Non-U.S. Gov't
Human leukocyte antigen system
education.field_of_study
Principal Component Analysis
Research Support, Non-U.S. Gov't
Single Nucleotide
3. Good health
Psychiatry and Mental health
Immune System Diseases
Schizophrenia
Female
medicine.medical_specialty
Population
Research Support
Polymorphism, Single Nucleotide
N.I.H
Polygenic risk score
Research Support, N.I.H., Extramural
SDG 3 - Good Health and Well-being
Predictive Value of Tests
Internal medicine
mental disorders
Journal Article
Humans
Bipolar disorder
Polymorphism
education
Biological Psychiatry
Type 1 diabetes
business.industry
Case-control study
Extramural
Immune dysregulation
medicine.disease
Case-Control Studies
Immunology
Immune disorder
business
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 09209964
- Volume :
- 159
- Issue :
- 2-3
- Database :
- OpenAIRE
- Journal :
- Schizophrenia Research
- Accession number :
- edsair.doi.dedup.....ce875617193bb0bbfabf31efc0ce5e0e