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Hematopoietic stem cell transplantation for autoimmune diseases in the time of COVID-19: EBMT guidelines and recommendations
- Source :
- Bone Marrow Transplantation, 56, 1493-1508. SPRINGERNATURE, Bone Marrow Transplantation
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Coronavirus disease-19 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), represents one of the biggest challenges of 21st century, threatening public health around the globe. Increasing age and presence of co-morbidities are reported risk factors for severe disease and mortality, along with autoimmune diseases (ADs) and immunosuppressive treatments such as haematopoietic stem cell transplantation (HSCT), which are also associated with adverse outcomes. We review the impact of the pandemic on specific groups of patients with neurological, rheumatological, and gastroenterological indications, along with the challenges delivering HSCT in adult and pediatric populations. Moving forward, we developed consensus-based guidelines and recommendations for best practice and quality of patient care in order to support clinicians, scientists, and their multidisciplinary teams, as well as patients and their carers. These guidelines aim to support national and international organizations related to autoimmune diseases and local clinical teams delivering HSCT. Areas of unmet need and future research questions are also highlighted. The waves of the COVID-19 pandemic are predicted to be followed by an “endemic” phase and therefore an ongoing risk within a “new normality”. These recommendations reflect currently available evidence, coupled with expert opinion, and will be revised according to necessary modifications in practice.
- Subjects :
- Feature
Adult
medicine.medical_specialty
Coronavirus disease 2019 (COVID-19)
medicine.medical_treatment
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Best practice
MEDLINE
Hematopoietic stem cell transplantation
Inflammatory bowel disease
Autoimmune Diseases
03 medical and health sciences
Rheumatic diseases
0302 clinical medicine
Pandemic
medicine
Humans
Hematologi
Child
Intensive care medicine
Pandemics
030203 arthritis & rheumatology
Transplantation
SARS-CoV-2
business.industry
Public health
Hematopoietic Stem Cell Transplantation
COVID-19
Hematology
Infectious diseases
Immunotherapy
business
Neurological disorders
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 02683369
- Database :
- OpenAIRE
- Journal :
- Bone Marrow Transplantation, 56, 1493-1508. SPRINGERNATURE, Bone Marrow Transplantation
- Accession number :
- edsair.doi.dedup.....ce884c954bfcd770273f3fc35a684fe6