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Parenteral Nutrition–Associated Hyperglycemia in Non–Critically Ill Inpatients Increases the Risk of In-Hospital Mortality (Multicenter Study)
- Source :
- Diabetes Care
- Publication Year :
- 2013
- Publisher :
- American Diabetes Association, 2013.
-
Abstract
- OBJECTIVE Hyperglycemia may increase mortality in patients who receive total parenteral nutrition (TPN). However, this has not been well studied in noncritically ill patients (i.e., patients in the nonintensive care unit setting). The aim of this study was to determine whether mean blood glucose level during TPN infusion is associated with increased mortality in noncritically ill hospitalized patients. RESEARCH DESIGN AND METHODS This prospective multicenter study involved 19 Spanish hospitals. Noncritically ill patients who were prescribed TPN were included prospectively, and data were collected on demographic, clinical, and laboratory variables as well as on in-hospital mortality. RESULTS The study included 605 patients (mean age 63.2 ± 15.7 years). The daily mean TPN values were 1.630 ± 323 kcal, 3.2 ± 0.7 g carbohydrates/kg, 1.26 ± 0.3 g amino acids/kg, and 0.9 ± 0.2 g lipids/kg. Multiple logistic regression analysis showed that the patients who had mean blood glucose levels >180 mg/dL during the TPN infusion had a risk of mortality that was 5.6 times greater than those with mean blood glucose levels CONCLUSIONS Hyperglycemia (mean blood glucose level >180 mg/dL) in noncritically ill patients who receive TPN is associated with a higher risk of in-hospital mortality.
- Subjects :
- Male
Research design
medicine.medical_specialty
Critical Illness
Endocrinology, Diabetes and Metabolism
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Risk of mortality
Humans
Hospital Mortality
Prospective Studies
Prospective cohort study
Aged
Original Research
Advanced and Specialized Nursing
In hospital mortality
business.industry
Critically ill
Clinical Care/Education/Nutrition/Psychosocial Research
Middle Aged
medicine.disease
Surgery
Parenteral nutrition
Multicenter study
Hyperglycemia
Female
Parenteral Nutrition, Total
business
Subjects
Details
- ISSN :
- 19355548 and 01495992
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Diabetes Care
- Accession number :
- edsair.doi.dedup.....ceb23616b1f309448d5d8f40dfa1ff86