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Racemic immunosuppressive seco-aporphine derivatives from Thalictrum wangii
- Source :
- Fitoterapia. 140:104445
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Thallactones A (1) and B (2), enantiomeric aporphine alkaloids with rare cleaved rings A and B, as well as thaliglucine N-oxide (3) and their biosynthetically related precursor, northalphenine (4), were isolated from the whole plant of Thalictrum wangii. Their structures with absolute configurations were elucidated by spectral techniques and electronic circular dichroism (ECD). Moreover, compounds 1, 3, and northalphenine inhibited concanavalin A (Con A)-stimulated proliferation of mice splenocyte significantly in a dose-dependent manner.
- Subjects :
- China
Circular dichroism
Aporphines
Thalictrum
Stereochemistry
Phytochemicals
01 natural sciences
Mice
chemistry.chemical_compound
Drug Discovery
Splenocyte
Animals
Aporphine
Pharmacology
Dose-Response Relationship, Drug
Molecular Structure
biology
010405 organic chemistry
Stereoisomerism
General Medicine
biology.organism_classification
0104 chemical sciences
010404 medicinal & biomolecular chemistry
chemistry
Concanavalin A
biology.protein
Enantiomer
Aporphine alkaloids
Immunosuppressive Agents
Spleen
Subjects
Details
- ISSN :
- 0367326X
- Volume :
- 140
- Database :
- OpenAIRE
- Journal :
- Fitoterapia
- Accession number :
- edsair.doi.dedup.....ceb7e7fb74836b43c250e8412ea5fad0
- Full Text :
- https://doi.org/10.1016/j.fitote.2019.104445