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Racemic immunosuppressive seco-aporphine derivatives from Thalictrum wangii

Authors :
Xiao-Dong Luo
Fei Gao
Pei-Feng Zhu
Xin Wei
Guy Sedar Singor Njateng
Ya-Ping Liu
Zhi Dai
Qiong Jin
Hai-Lian Yuan
Xu-Jie Qin
Source :
Fitoterapia. 140:104445
Publication Year :
2020
Publisher :
Elsevier BV, 2020.

Abstract

Thallactones A (1) and B (2), enantiomeric aporphine alkaloids with rare cleaved rings A and B, as well as thaliglucine N-oxide (3) and their biosynthetically related precursor, northalphenine (4), were isolated from the whole plant of Thalictrum wangii. Their structures with absolute configurations were elucidated by spectral techniques and electronic circular dichroism (ECD). Moreover, compounds 1, 3, and northalphenine inhibited concanavalin A (Con A)-stimulated proliferation of mice splenocyte significantly in a dose-dependent manner.

Details

ISSN :
0367326X
Volume :
140
Database :
OpenAIRE
Journal :
Fitoterapia
Accession number :
edsair.doi.dedup.....ceb7e7fb74836b43c250e8412ea5fad0
Full Text :
https://doi.org/10.1016/j.fitote.2019.104445