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Disease-specific Proteins from Rheumatoid Arthritis Patients
- Source :
- Journal of Korean Medical Science
- Publication Year :
- 2006
- Publisher :
- The Korean Academy of Medical Sciences, 2006.
-
Abstract
- Rheumatoid arthritis (RA) is a chronic inflammatiory disease that mainly destroys cartilages or bones at the joints. This inflammatory disorder is initiated by self-attack using own immune system, but the detail of pathological mechanism is unclear. Features of autoantigens leading to autoimmune disease are also under veil although several candidates including type II collagen have been suggested to play a role in pathogenesis. In this report, we tried to identify proteins responding to antibodies purified from RA patients and screen proteins up-regulated or down-regulated in RA using proteomic approach. Fibronectin, semaphorin 7A precursor, growth factor binding protein 7 (GRB7), and immunoglobulin µ chain were specifically associated with antibodies isolated from RA synovial fluids. In addition, some metabolic proteins such as adipocyte fatty acid binding protein, galectin-1 and apolipoprotein A1 precursor were overexpressed in RA synovium. Also, expression of peroxiredoxin 2 was up-regulated in RA. On the contrary, expression of vimentin was severely suppressed in RA synoviocytes. Such findings might give some insights into understanding of pathological mechanism in RA.
- Subjects :
- Proteomics
Adult
Male
Vimentin
Inflammation
Peroxiredoxin 2
Biology
Autoantigens
Pathogenesis
Arthritis, Rheumatoid
Semaphorin
Synovial Fluid
medicine
Synovial fluid
Humans
Collagen Type II
Aged
Autoimmune disease
Sepharose
General Medicine
Middle Aged
medicine.disease
Fibronectins
Gene Expression Regulation
Immunology
biology.protein
Original Article
Female
medicine.symptom
Antibody
Subjects
Details
- Language :
- English
- ISSN :
- 15986357 and 10118934
- Volume :
- 21
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of Korean Medical Science
- Accession number :
- edsair.doi.dedup.....ced7acc63ad50d85e9930f0ddc373b9e