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Usefulness of phalangeal quantitative ultrasound in identifying reduced bone mineral status and increased fracture risk in adolescents with Turner syndrome
- Source :
- Hormones (Athens, Greece). 13(3)
- Publication Year :
- 2014
-
Abstract
- OBJECTIVE. Bone health is a major concern in patients with Turner syndrome (TS). There are few studies assessing bone mineral status in TS adolescents and none have reported a clear relationship with the risk of fracture. We assessed bone mineral status at three different skeletal sites by two different densitometric techniques in a group of TS adolescents. DESIGN. In 24 TS adolescents (17.1 ± 3.1 years) we evaluated lumbar and femoral volumetric bone mineral density (vBMD) with dual energy X-ray absorptiometry (DXA), amplitude-dependent speed of sound (AD-SoS) and bone transmission time (BTT) with phalangeal quantitative ultrasound (QUS). RESULTS. Mean lumbar vBMD Z-score was normal, while mean femoral vBMD, ADSoS and BTT Z-score were reduced. 8/24 (33.3%) and 13/24 (54.2%) girls had AD-SoS and BTT ≤-2 Z-score, respectively, while lumbar vBMD and femoral vBMD were ≤-2 Z-score only in 2/24 (8.4%) and 1/24 (4.2%) patients. Overall, we documented 15 fractures (three pathological) in 8 girls. Patients who reported at least one fracture had lower AD-SoS and BTT Z-score values than fracture-free girls. The presence of a value of BTT ≤-2.0 Z-score was associated with a significant OR of positive history of fracture of 11.67 (χ2 = 5.906, p =0.015, C.I. 95% 1.14–119.54). Lumbar and femoral vBMD were not related to fracture risk. CONCLUSIONS. TS adolescents may have impaired bone mineral status in skeletal sites with predominant cortical bone. Phalangeal QUS represents a useful method to identify subjects with increased fracture risk.
- Subjects :
- Fracture risk
medicine.medical_specialty
Bone mineral status, Dual energy X-ray absorptiometry, Quantitative ultrasound, Turner syndrome
Bone mineral status
Adolescent
Endocrinology, Diabetes and Metabolism
Dentistry
Turner Syndrome
Risk Assessment
Dual energy X-ray absorptiometry
Finger Phalanges
Young Adult
Lumbar
Absorptiometry, Photon
Sex Factors
Bone Density
Predictive Value of Tests
Risk Factors
Turner syndrome
medicine
Humans
Femur
Child
Pathological
Dual-energy X-ray absorptiometry
Ultrasonography
Bone mineral
Chi-Square Distribution
Lumbar Vertebrae
medicine.diagnostic_test
business.industry
Age Factors
General Medicine
medicine.disease
Prognosis
Quantitative ultrasound
medicine.anatomical_structure
Cortical bone
Female
Radiology
business
Osteoporotic Fractures
Subjects
Details
- ISSN :
- 25208721
- Volume :
- 13
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Hormones (Athens, Greece)
- Accession number :
- edsair.doi.dedup.....cedaa83ef995c7377dd169c09eadc3d1