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Acute Kidney Injury After Repeated Exposure to Contrast Material for Coronary Angiography
- Source :
- Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 5, Iss 1, Pp 46-54 (2021), Mayo Clinic Proceedings: Innovations, Quality & Outcomes
- Publication Year :
- 2021
- Publisher :
- Elsevier, 2021.
-
Abstract
- Objective To assess the incidence of contrast-associated acute kidney injury (CAAKI) after repeated exposure to contrast material for computed tomography (CT) and conventional coronary angiography within short intervals. Methods We studied 651 patients enrolled in the CorE-64 (November 5, 2005–January 30, 2007) and CORE320 (October 21, 2009–August 17, 2011) multicenter studies. Participants with suspected obstructive coronary heart disease were referred for diagnostic cardiac catheterization and underwent coronary CT angiography for research before invasive angiography. Nonionic, low-osmolality iodinated contrast material was used for all imaging. Results The median age of the patients was 62 years, and 190 (29%) were women. Major risk factors for acute kidney injury were present in 277 of 651 (43%) patients. The median interval between CT imaging and invasive angiography was 3.1 days (interquartile range, 0.9-8.0 days). The median volume of contrast material was 100 mL for each test. In 16 (2.5%) of 651 patients, CAAKI developed. Of these cases, 1 occurred after the CT scan, whereas 6 were documented after invasive angiography (compared with post-CT creatinine concentration assessment). In 9 patients, CAAKI was found in comparing creatinine concentration after completion of both tests with baseline values (but not compared with post-CT imaging). Conclusion Acute kidney injury after repeated exposure to iodinated contrast media within a few days is uncommon even in a population of patients with highly prevalent risk factors. Withholding of clinically indicated contrast-enhanced imaging may therefore not be justified in this setting.
- Subjects :
- medicine.medical_specialty
CAAKI, contrast-associated acute kidney injury
medicine.medical_treatment
Population
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Iodinated contrast
Interquartile range
medicine
030212 general & internal medicine
education
IQR, interquartile range
Cardiac catheterization
Computed tomography angiography
education.field_of_study
PCI, percutaneous coronary intervention
lcsh:R5-920
medicine.diagnostic_test
SE, standard error
business.industry
ICA, invasive coronary angiography
Acute kidney injury
Percutaneous coronary intervention
medicine.disease
Angiography
Original Article
Radiology
CTA, computed tomography angiography
business
lcsh:Medicine (General)
Subjects
Details
- Language :
- English
- ISSN :
- 25424548
- Volume :
- 5
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Mayo Clinic Proceedings: Innovations, Quality & Outcomes
- Accession number :
- edsair.doi.dedup.....ceed457f2a5422f6a737f363f3f00a6b