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Clinical characteristics of post-traumatic epilepsy and the factors affecting the latency of PTE
- Source :
- BMC Neurology, Vol 21, Iss 1, Pp 1-11 (2021), BMC Neurology
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Objectives To summarize the clinical characteristics of post-traumatic epilepsy (PTE), and to identify the factors affecting the latency of PTE after traumatic brain injury (TBI). Methods We conducted a retrospective clinical analysis in patients with PTE who visited the outpatient Department of Epilepsy, Beijing Tiantan Hospital from January 2013 to December 2018. The clinical characteristics, including gender, age distribution, seizure type, and latency were summarized. Factors affecting the latency of PTE were evaluated using Kaplan-Meier curves and Cox proportional hazard regression analysis. Results Complete clinical information was available for 2862 subjects, of which 78.48% were males. The mean age at TBI was 21.4 ± 15.1 years and peaked in the 0 to 12-year-old and 15 to 27-year-old groups. Generalized onset seizure was the most frequent seizure type (72.82% of patients). Approximately 19.95% PTE patients developed drug-resistant epilepsy. The latency of PTE ranged from 8 days to 20 years, with a median of 24.0 (IQR, 5.0–84.0) months. The Kaplan-Meier curves demonstrated that gender, age at TBI, severity of TBI, multiple craniocerebral injuries, post-TBI treatments, acute seizures, and residual disability were associated with PTE latency. The Cox regression model indicated that age ≥ 18 years old, severe TBI with multiple surgical operations, acute seizures, and residual disability were risk factors for shorter PTE latency. Conclusions PTE is more common in males than females, and peaked in the 0 to 12-year-old and 15 to 27-year-old groups. Generalized onset seizure was the most common seizure type and 19.95% of participants developed drug-resistant epilepsy. Patients aged ≥18 years old, who suffered severe TBI followed by multiple surgical operations, experienced acute seizures, or with residual disabilities had shorter PTE latency.
- Subjects :
- Adult
Male
medicine.medical_specialty
Pediatrics
Neurology
Adolescent
Traumatic brain injury
Epilepsy
Young Adult
Seizures
Brain Injuries, Traumatic
medicine
Outpatient clinic
Humans
Post-traumatic epilepsy
Child
RC346-429
Retrospective Studies
Clinical pathology
Clinical characteristics
Proportional hazards model
business.industry
Infant, Newborn
Infant
General Medicine
medicine.disease
Epilepsy, Post-Traumatic
Risk factors
Child, Preschool
Latency
Female
Neurology (clinical)
Neurosurgery
Neurology. Diseases of the nervous system
business
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712377
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Neurology
- Accession number :
- edsair.doi.dedup.....cf03ab750108fb5c8a6b55c4bc778970