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Increased HIV-1 activity in anal high-grade squamous intraepithelial lesions compared with unaffected anal mucosa in men who have sex with men
- Source :
- Clinical infectious diseases, 58(11), 1634-1637. Oxford University Press
- Publication Year :
- 2014
-
Abstract
- We studied 3 patients with focal intra-anal tissue high-grade squamous intraepithelial lesions (HSILs). All had increased human immunodeficiency virus type 1 (HIV-1) RNA and DNA in lesions compared with that in healthy mucosa. HIV-1 RNA and HIV-1 episomal DNA were indicative of ongoing viral replication, more so in anal HSILs.
- Subjects :
- Microbiology (medical)
Male
Pathology
medicine.medical_specialty
Sexual Behavior
Human immunodeficiency virus (HIV)
HIV Infections
medicine.disease_cause
Anal Mucosa
Men who have sex with men
chemistry.chemical_compound
medicine
Humans
Homosexuality, Male
Intestinal Mucosa
business.industry
RNA
Mucous membrane
virus diseases
Viral Load
Anus
Anus Neoplasms
Infectious Diseases
medicine.anatomical_structure
Viral replication
chemistry
DNA, Viral
Carcinoma, Squamous Cell
HIV-1
RNA, Viral
business
DNA
Carcinoma in Situ
Subjects
Details
- Language :
- English
- ISSN :
- 10584838
- Volume :
- 58
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Clinical infectious diseases
- Accession number :
- edsair.doi.dedup.....cf09039bb8c7dc28c483aeda095ed594
- Full Text :
- https://doi.org/10.1093/cid/ciu133