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Acute Effects of Dietary Nitrate on Exercise Tolerance, Muscle Oxygenation, and Cardiovascular Function in Patients With Peripheral Arterial Disease
- Source :
- International Journal of Sport Nutrition and Exercise Metabolism, 31, 5, pp. 385-396, International Journal of Sport Nutrition and Exercise Metabolism, 31(5), 385-396. Human Kinetics Publishers, International Journal of Sport Nutrition and Exercise Metabolism, 31, 385-396
- Publication Year :
- 2021
-
Abstract
- Previous studies have used supplements to increase dietary nitrate intake in clinical populations. Little is known about whether effects can also be induced through vegetable consumption. Therefore, the aim of this study was to assess the impact of dietary nitrate, through nitrate-rich vegetables (NRV) and beetroot juice (BRJ) supplementation, on plasma nitrate and nitrite concentrations, exercise tolerance, muscle oxygenation, and cardiovascular function in patients with peripheral arterial disease. In a randomized crossover design, 18 patients with peripheral arterial disease (age: 73 ± 8 years) followed a nitrate intake protocol (∼6.5 mmol) through the consumption of NRV, BRJ, and nitrate-depleted BRJ (placebo). Blood samples were taken, blood pressure and arterial stiffness were measured in fasted state and 150 min after intervention. Each intervention was followed by a maximal walking exercise test to determine claudication onset time and peak walking time. Gastrocnemius oxygenation was measured by near-infrared spectroscopy. Blood samples were taken and blood pressure was measured 10 min after exercise. Mean plasma nitrate and nitrite concentrations increased (nitrate; Time × Intervention interaction; p p p = .762 and p = .165, respectively). Gastrocnemius oxygenation, blood pressure, and arterial stiffness were not affected by the intervention. NRV and BRJ intake markedly increase plasma nitrate and nitrite, but this does not translate to improved exercise tolerance, muscle oxygenation, and/or cardiovascular function.
- Subjects :
- 0301 basic medicine
NEAR-INFRARED SPECTROSCOPY
Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]
Medicine (miscellaneous)
Blood Pressure
BLOOD-PRESSURE
functional capacity
030204 cardiovascular system & hematology
Beetroot Juice
0302 clinical medicine
cardiovascular disease
Orthopedics and Sports Medicine
ERGOGENIC AID
BEETROOT JUICE SUPPLEMENTATION
Aged, 80 and over
Nutrition and Dietetics
Cross-Over Studies
Exercise Tolerance
General Medicine
INTENSITY EXERCISE
PLASMA NITRITE
Fruit and Vegetable Juices
Cardiology
HEART-FAILURE
INORGANIC NITRATE
medicine.symptom
Beta vulgaris
medicine.medical_specialty
exercise performance
Placebo
CAPACITY
03 medical and health sciences
Peripheral Arterial Disease
All institutes and research themes of the Radboud University Medical Center
Double-Blind Method
Internal medicine
medicine
Humans
Muscle, Skeletal
Aged
claudication
Nitrates
nitrate-rich vegetables
business.industry
Metabolic Disorders Radboud Institute for Health Sciences [Radboudumc 6]
Oxygenation
PERFORMANCE
medicine.disease
Crossover study
030104 developmental biology
Blood pressure
Heart failure
Dietary Supplements
Arterial stiffness
Claudication
business
Subjects
Details
- ISSN :
- 1526484X
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- International Journal of Sport Nutrition and Exercise Metabolism
- Accession number :
- edsair.doi.dedup.....cf26537a01468acc7be8fb4b4b1602b1
- Full Text :
- https://doi.org/10.1123/ijsnem.2021-0054