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Mitotic index, microvascular proliferation, and necrosis define 3 groups of 1p/19q codeleted anaplastic oligodendrogliomas associated with different genomic alterations
- Source :
- Neuro-Oncology, Neuro-Oncology, 2014, 16 (9), pp.1244-1254. ⟨10.1093/neuonc/nou047⟩, Neuro-Oncology, Oxford University Press (OUP), 2014, 16 (9), pp.1244-1254. ⟨10.1093/neuonc/nou047⟩
- Publication Year :
- 2014
- Publisher :
- HAL CCSD, 2014.
-
Abstract
- BACKGROUND: The aim of this study was to correlate histological features and molecular characteristics in anaplastic oligodendrogliomas (AO). METHODS: The histological characteristics of 203 AO patients enrolled in the French national network POLA were analyzed. The genomic profiles of 191 cases were studied using genomic arrays. IDH mutational status was assessed by immunohistochemistry and direct sequencing. RESULTS: 1p/19q co-deletion was present in 79% of cases and was associated with alpha-internexin expression (p < 10-4), IDH1/2 mutation (p < 10-4), chromosome 4 loss (p < 10-3), and better overall survival (p < 10-4). Based on mitotic index, microvascular proliferation (MVP) and necrosis, 3 groups of 1p/19q co-deleted AO were identified: AO with more than 5 mitoses per 10-HPF, no MVP and no necrosis, (1), AO with MVP and no necrosis (2) and AO with MVP and necrosis (3). Compared to group 1, group 2 and 3 AO had a higher mean Ki-67 proliferation index and a higher rate of 9p and 9q losses. Compared to group 2, group 3 AO had a higher number of chromosomal alterations including chromosome 4 loss. In the subgroup of 157 1p/19q co-deleted AO, chromosomal instability was associated with shorter progression free survival (p = 0.024) and shorter overall survival (p = 0.023). CONCLUSIONS: The present study shows that oligodendroglioma with classic histological features remains a molecularly heterogeneous entity and should be stratified according to 1p/19q status because of its major prognostic relevance. Moreover, 1p/19q co-deleted AO are also heterogeneous. Interestingly, mitotic index, MVP and necrosis help to classify them into three groups associated with distinct genomic alterations.
- Subjects :
- Cancer Research
Pathology
medicine.medical_specialty
IDH1
Necrosis
Mitotic index
Proliferation index
[SDV]Life Sciences [q-bio]
Oligodendroglioma
Biology
Disease-Free Survival
03 medical and health sciences
0302 clinical medicine
Chromosome instability
medicine
Mitotic Index
Humans
Progression-free survival
ComputingMilieux_MISCELLANEOUS
Neovascularization, Pathologic
Brain Neoplasms
Brain
medicine.disease
Isocitrate Dehydrogenase
3. Good health
Oncology
Chromosomes, Human, Pair 1
030220 oncology & carcinogenesis
Basic and Translational Investigations
Chromosome abnormality
Neurology (clinical)
medicine.symptom
Chromosome Deletion
Chromosomes, Human, Pair 19
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 15228517 and 15235866
- Database :
- OpenAIRE
- Journal :
- Neuro-Oncology, Neuro-Oncology, 2014, 16 (9), pp.1244-1254. ⟨10.1093/neuonc/nou047⟩, Neuro-Oncology, Oxford University Press (OUP), 2014, 16 (9), pp.1244-1254. ⟨10.1093/neuonc/nou047⟩
- Accession number :
- edsair.doi.dedup.....cf36256d75fceb25fdc62807637b256c