Are individual analyses of multiple short urine collections throughout the 24 hours superior to a standard 24-hour urine collection in precipitation risk assessment of healthy subjects?

PURPOSE The commonly used 24-hour collection technique has been the mainstay of diagnosis for supersaturation but has some certain limitations. Hence, superiority of multiple short urine collections as a new alternative in precipitation risk assessment was assessed compared to the standard 24-hour urine collection among healthy subjects. MATERIALS AND METHODS Individual urine samples of 26 healthy subjects were acquired every 2 to 3 hours throughout the 24 hours. Urine samples were obtained and the time and volume of each sample were recorded. Urinary constituents involved in precipitation including, sodium-potassium, chloride, calcium, phosphate, citrate, magnesium, urea, creatinine and pH were measured. A simulated 24-hour collection was recalculated by the totalling of all shorter urine collections volume and urinary constituents excretions throughout the day. RESULTS Urine pH, urine creatinine and precipitation rate had a significantly lower values in 24-hours urine collection compared to one individual value of multiple urine collections by -0.769 (P