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The bioavailability of different zinc compounds used as human dietary supplements in rat prostate: a comparative study
- Source :
- Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine. 27(3)
- Publication Year :
- 2013
-
Abstract
- The normal human prostate accumulates the highest levels of zinc (Zn) of any soft tissue in the body. The pool of zinc available to the body is known to significantly decrease with age. It is suggested that dietary Zn supplementation protects against oxidative damage and reduces the risk of cancer. Zinc sulfate and zinc gluconate were the most frequently mentioned in per os administration in studies on Zn supplementation. The major aim of the study was to compare the bioavailability of different Zn compounds (sulfate, gluconate and citrate) in the prostate after their daily administration to male rats at three different doses (3.0; 15.0; and 50.0 mg Zn/kg b.w.) for 30 days. The results show that bioavailability in the prostate differs significantly between individual zinc preparations. A significantly elevated Zn concentration in the dorso-lateral lobe of the prostate, compared to controls, was found in the rats supplemented with two compounds only: zinc gluconate and zinc citrate. However, after administration of zinc gluconate, this effect occurred even at the lowest dose. The lowest zinc bioavailability in the prostate was found in the rats administered zinc sulfate: no significant Zn increase was seen in particular zones of the prostate. To sum up, the use of zinc gluconate is worth considering as a possible means of zinc supplementation in men.
- Subjects :
- Male
medicine.medical_specialty
Zinc compounds
chemistry.chemical_element
Biological Availability
Zinc
Kidney
Weight Gain
Gluconates
General Biochemistry, Genetics and Molecular Biology
Citric Acid
Biomaterials
chemistry.chemical_compound
Prostate
Internal medicine
Malondialdehyde
Male rats
medicine
Animals
Humans
Sulfate
Rats, Wistar
Glutathione Peroxidase
Superoxide Dismutase
Metals and Alloys
Kidney metabolism
Glutathione
Zinc Sulfate
Bioavailability
Rat Prostate
medicine.anatomical_structure
Endocrinology
chemistry
Liver
Dietary Supplements
General Agricultural and Biological Sciences
Copper
Subjects
Details
- ISSN :
- 15728773
- Volume :
- 27
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
- Accession number :
- edsair.doi.dedup.....cf3b8f5cbe804877ec9bd57462949e55