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Select your SNPs (SYSNPs): A web tool for automatic and massive selection of SNPs
- Source :
- Digital.CSIC. Repositorio Institucional del CSIC, instname, International Journal of Data Mining and Bioinformatics, r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF), Centro de Investigación Principe Felipe (CIPF), r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
- Publication Year :
- 2012
- Publisher :
- Inderscience Publishers, 2012.
-
Abstract
- Lorente-Galdós, Belén et al.<br />Association studies are the choice approach in the discovery of the genomic basis of complex traits. To carry out such analysis, researchers frequently need to (1) select optimally informative sets of Single Nucleotide Polymorphisms (SNPs) in candidate regions and (2) annotate the results of associations found by means of genome-wide SNP arrays. These are complex tasks, since many criteria have to be considered, including the SNPs' functional properties, technological information and haplotype frequencies in given populations. SYSNPs implements algorithms that allow for efficient and simultaneous consideration of all the relevant criteria to obtain sets of SNPs that properly cover arbitrarily large lists of genes or genomic regions. Complementarily, SYSNPs allows for comprehensive functional annotation of SNPs linked to any given marker SNP. SYSNPs dramatically reduces the effort needed for SNP selection from days of searching various databases to a few minutes using a simple browser. © 2012 Inderscience Enterprises Ltd.
- Subjects :
- tag-SNPs
Genome-wide association study
SNP-arrays
PUPASuite
Single-nucleotide polymorphism
Computational biology
Library and Information Sciences
Biology
Polymorphism, Single Nucleotide
General Biochemistry, Genetics and Molecular Biology
Association
Databases, Genetic
Tagger
Linkage disequilibrium
SNP
PupaSuite
Selection (genetic algorithm)
Genetic association
Genetics
Internet
complex disease
Genomics
Sequence Analysis, DNA
Single nucleotide polymorphisms
Tag SNP
SNP genotyping
Complex diseases
Algorithms
Software
Information Systems
SNPs
Subjects
Details
- ISSN :
- 17485673
- Database :
- OpenAIRE
- Journal :
- Digital.CSIC. Repositorio Institucional del CSIC, instname, International Journal of Data Mining and Bioinformatics, r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF), Centro de Investigación Principe Felipe (CIPF), r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
- Accession number :
- edsair.doi.dedup.....cf3e48416d9ae36fc7568b56128888b3