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Patients Affected by Unmethylated O(6)-Methylguanine-DNA Methyltransferase Glioblastoma Undergoing Radiochemotherapy May Benefit from Moderately Dose-Escalated Radiotherapy
- Source :
- BioMed Research International, BioMed Research International, Vol 2017 (2017)
- Publication Year :
- 2017
- Publisher :
- Hindawi, 2017.
-
Abstract
- Purpose. To compare the therapeutic results of two radiotherapy (RT) dose schedules in combined temozolomide- (TMZ-) RT treatment in newly diagnosed glioblastoma (GB), according to the O(6)-methylguanine-DNA methyltransferase (MGMT) methylation status.Material and Method. Patients received either standard (60 Gy) or moderately escalated dose (70 Gy) radiotherapy (RT) with concomitant and adjuvant TMZ between June 2006 and October 2013. We retrospectively evaluated the therapeutic effectiveness of RT schedules in terms of Overall Survival (OS) and Progression-Disease Free Survival (PDFS) analyzing the MGMT methylation status.Results. One hundred and seventeen patients were selected for the present analysis. Seventy-two out of the selected cases received the standard RT-TMZ course (SDRT-TMZ) whereas the remaining 45 underwent the escalated schedule (HDRT-TMZ). The analysis according to the MGMT promoter methylation status showed that, in unmethylated-MGMT GB patients, HDRT-TMZ and SDRT-TMZ groups had different median OS (p=0,01) and PDFS (p=0,007), that is, 8 months and 5 months for the SDRT-TMZ group and 14 months and 9 months for the HDRT-TMZ group, respectively. No difference in survival outcomes was found in methylated MGMT patients according to the two RT schedules (p=0,12).Conclusions. In our experience, unmethylated-MGMT GB patients benefited from a moderately escalated dose of RT plus TMZ.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Methyltransferase
Article Subject
medicine.medical_treatment
Dacarbazine
lcsh:Medicine
Disease-Free Survival
General Biochemistry, Genetics and Molecular Biology
O(6)-Methylguanine-DNA Methyltransferase
03 medical and health sciences
0302 clinical medicine
Internal medicine
Temozolomide
Humans
Medicine
Promoter Regions, Genetic
Aged
General Immunology and Microbiology
business.industry
lcsh:R
O-6-methylguanine-DNA methyltransferase
Dose-Response Relationship, Radiation
Chemoradiotherapy
General Medicine
DNA Methylation
Middle Aged
Combined Modality Therapy
Surgery
Radiation therapy
030220 oncology & carcinogenesis
Concomitant
Female
Glioblastoma
business
Adjuvant
030217 neurology & neurosurgery
Research Article
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 23146133
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....cf4e4262ee23dee9ac8979711dc38a0b
- Full Text :
- https://doi.org/10.1155/2017/9461402