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Natural α-Glucosidase and Protein Tyrosine Phosphatase 1B Inhibitors: A Source of Scaffold Molecules for Synthesis of New Multitarget Antidiabetic Drugs
- Source :
- Molecules, Molecules, Vol 26, Iss 4818, p 4818 (2021)
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Diabetes mellitus (DM) represents a group of metabolic disorders that leads to acute and long-term serious complications and is considered a worldwide sanitary emergence. Type 2 diabetes (T2D) represents about 90% of all cases of diabetes, and even if several drugs are actually available for its treatment, in the long term, they show limited effectiveness. Most traditional drugs are designed to act on a specific biological target, but the complexity of the current pathologies has demonstrated that molecules hitting more than one target may be safer and more effective. The purpose of this review is to shed light on the natural compounds known as α-glucosidase and Protein Tyrosine Phosphatase 1B (PTP1B) dual-inhibitors that could be used as lead compounds to generate new multitarget antidiabetic drugs for treatment of T2D.
- Subjects :
- Pharmaceutical Science
Review
Type 2 diabetes
Pharmacology
Analytical Chemistry
QD241-441
Diabetes mellitus
Drug Discovery
medicine
Humans
Hypoglycemic Agents
Glycoside Hydrolase Inhibitors
Enzyme Inhibitors
Physical and Theoretical Chemistry
insulin signaling
Protein Tyrosine Phosphatase, Non-Receptor Type 1
biology
Drug discovery
business.industry
α glucosidase
Organic Chemistry
PTP1B
alpha-Glucosidases
medicine.disease
Protein Tyrosine Phosphatase 1B
Insulin receptor
Diabetes Mellitus, Type 2
Chemistry (miscellaneous)
Biological target
biology.protein
Molecular Medicine
α-glucosidase
type 2 diabetes
business
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....cf5114694eaf3e82744790a14ed3fe9d