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Acute Administration of Exogenous Lactate Increases Carbohydrate Metabolism during Exercise in Mice

Acute Administration of Exogenous Lactate Increases Carbohydrate Metabolism during Exercise in Mice

Authors :
Sunghwan Kyun
Kiwon Lim
Jisu Kim
Deunsol Hwang
Inkwon Jang
Source :
Metabolites, Volume 11, Issue 8, Metabolites, Vol 11, Iss 553, p 553 (2021)
Publication Year :
2021
Publisher :
Multidisciplinary Digital Publishing Institute, 2021.

Abstract

In this study, we investigated the effects of exogenous lactate administration before exercise on energy substrate utilization during exercise. Mice were divided into exercise control (EX) and exercise with lactate intake (EXLA) groups<br />saline/lactate was administered 30 min before exercise. Respiratory gas was measured during moderate intensity treadmill exercise (30 min). Immediately after exercise, blood, liver, and skeletal muscle samples were collected and mRNA levels of energy metabolism-related and metabolic factors were analyzed. At 16–30 min of exercise, the respiratory exchange ratio (p = 0.045) and carbohydrate oxidation level (p = 0.014) were significantly higher in the EXLA than in the EX group. Immediately after exercise, the muscle and liver glycogen content and blood glucose level of the EXLA group were lower than those of the EX group. In addition, muscle mRNA levels of HK2 (hexokinase 2<br />p = 0.009), a carbohydrate oxidation-related factor, were higher in the EXLA than in the EX group, whereas the expression of PDK4 (pyruvate dehydrogenase kinase 4<br />p = 0.001), CS (citrate synthase<br />p = 0.045), and CD36 (cluster of differentiation 36<br />p = 0.002), factors related to oxidative metabolism, was higher in the EX than in the EXLA group. These results suggest that lactate can be used in various research fields to promote carbohydrate metabolism.

Details

Language :
English
ISSN :
22181989
Database :
OpenAIRE
Journal :
Metabolites
Accession number :
edsair.doi.dedup.....cf542ba64fb080fafc923820975035ba
Full Text :
https://doi.org/10.3390/metabo11080553