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Acute Administration of Exogenous Lactate Increases Carbohydrate Metabolism during Exercise in Mice
Acute Administration of Exogenous Lactate Increases Carbohydrate Metabolism during Exercise in Mice
- Source :
- Metabolites, Volume 11, Issue 8, Metabolites, Vol 11, Iss 553, p 553 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- In this study, we investigated the effects of exogenous lactate administration before exercise on energy substrate utilization during exercise. Mice were divided into exercise control (EX) and exercise with lactate intake (EXLA) groups<br />saline/lactate was administered 30 min before exercise. Respiratory gas was measured during moderate intensity treadmill exercise (30 min). Immediately after exercise, blood, liver, and skeletal muscle samples were collected and mRNA levels of energy metabolism-related and metabolic factors were analyzed. At 16–30 min of exercise, the respiratory exchange ratio (p = 0.045) and carbohydrate oxidation level (p = 0.014) were significantly higher in the EXLA than in the EX group. Immediately after exercise, the muscle and liver glycogen content and blood glucose level of the EXLA group were lower than those of the EX group. In addition, muscle mRNA levels of HK2 (hexokinase 2<br />p = 0.009), a carbohydrate oxidation-related factor, were higher in the EXLA than in the EX group, whereas the expression of PDK4 (pyruvate dehydrogenase kinase 4<br />p = 0.001), CS (citrate synthase<br />p = 0.045), and CD36 (cluster of differentiation 36<br />p = 0.002), factors related to oxidative metabolism, was higher in the EX than in the EXLA group. These results suggest that lactate can be used in various research fields to promote carbohydrate metabolism.
- Subjects :
- medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
PDK4
supplement
Carbohydrate metabolism
Microbiology
Biochemistry
carbohydrate oxidation
Article
chemistry.chemical_compound
Internal medicine
medicine
Citrate synthase
exogenous lactate
Molecular Biology
Respiratory exchange ratio
biology
Glycogen
exercise
Chemistry
Skeletal muscle
Metabolism
Carbohydrate
QR1-502
medicine.anatomical_structure
Endocrinology
biology.protein
metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 22181989
- Database :
- OpenAIRE
- Journal :
- Metabolites
- Accession number :
- edsair.doi.dedup.....cf542ba64fb080fafc923820975035ba
- Full Text :
- https://doi.org/10.3390/metabo11080553