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Polymorphisms of XRCC4 are involved in reduced colorectal cancer risk in Chinese schizophrenia patients
- Source :
- BMC Cancer, Vol 10, Iss 1, p 523 (2010), BMC Cancer
- Publisher :
- Springer Nature
-
Abstract
- Background Genetic factors related to the regulation of apoptosis in schizophrenia patients may be involved in a reduced vulnerability to cancer. XRCC4 is one of the potential candidate genes associated with schizophrenia which might induce colorectal cancer resistance. Methods To examine the genetic association between colorectal cancer and schizophrenia, we analyzed five SNPs (rs6452526, rs2662238, rs963248, rs35268, rs2386275) covering ~205.7 kb in the region of XRCC4. Results We observed that two of the five genetic polymorphisms showed statistically significant differences between 312 colorectal cancer subjects without schizophrenia and 270 schizophrenia subjects (rs6452536, p = 0.004, OR 0.61, 95% CI 0.44-0.86; rs35268, p = 0.028, OR 1.54, 95% CI 1.05-2.26). Moreover, the haplotype which combined all five markers was the most significant, giving a global p = 0.0005. Conclusions Our data firstly indicate that XRCC4 may be a potential protective gene towards schizophrenia, conferring reduced susceptibility to colorectal cancer in the Han Chinese population.
- Subjects :
- Male
Oncology
China
medicine.medical_specialty
Cancer Research
Colorectal cancer
Single-nucleotide polymorphism
Comorbidity
Biology
Polymorphism, Single Nucleotide
lcsh:RC254-282
Internal medicine
Genotype
medicine
Genetics
Humans
Genetic Predisposition to Disease
Allele
Aged
Genetic association
Polymorphism, Genetic
Haplotype
Cancer
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
DNA-Binding Proteins
Haplotypes
Schizophrenia
Female
Colorectal Neoplasms
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 14712407
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Cancer
- Accession number :
- edsair.doi.dedup.....cf6e8b42db2a4f462ca3bf07d8069ddc
- Full Text :
- https://doi.org/10.1186/1471-2407-10-523