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The neural and neuro-endocrine component of the human thymus II. Hormone immunoreactivity
- Source :
- Brain, Behavior, and Immunity. 6:249-264
- Publication Year :
- 1992
- Publisher :
- Elsevier BV, 1992.
-
Abstract
- We evaluated the presence of anterior pituitary hormones; follicle-stimulating hormone (FSH) and its beta-subunit (beta-FSH), luteinizing hormone (LH) and its beta-subunit (beta-LH), beta-subunit of thyroid-stimulating hormone (beta-TSH), adrenocorticotropic hormone (ACTH), growth hormone (GH), and prolactin (PRL); the placental hormone human chorionic gonadotropin (hCG); and somatostatin, in paraffin and frozen sections of the human thymus. Epithelial cells in the medulla were immunoreactive for most of these hormones, in varying density and intensity of labeling. The cells labeled varied from epithelial cells surrounding Hassall's corpuscles toward solitary cells or small epithelial aggregates in the medulla. FSH immunoreactivity did occur predominantly in epithelial cells of the cortex, in apparent contrast to the predominant medullary location of cells immunolabeled for beta-FSH. The epithelial nature of FSH-immunoreactive cells was confirmed by two-color immunohistochemistry with anti-keratin antibody. In addition to FSH, some epithelial cells in subcapsule and cortex were labeled by antibodies to beta-FSH, beta-LH, beta-TSH, ACTH, GH, and PRL. Some macrophage-like cells surrounded by a rosette of lymphocytes were immunoreactive for FSH and GH. Some interdigitating reticulum-like cells were labeled by anti-beta-LH. Immunolabeling of lymphocytes was found for hCG, especially lymphocytes in the medulla. Two-color immunohistochemistry with anti-CD3 revealed a strong CD3 expression on hCG-immunoreactive cells, whereas CD3-negative cells were hCG-negative. T cells immunolabeled for hCG were also found in peripheral lymphoid organs.
- Subjects :
- Male
endocrine system
medicine.medical_specialty
Adolescent
CD3 Complex
Neuroimmunomodulation
medicine.drug_class
Immunology
Thymus Gland
Adrenocorticotropic hormone
Peptide hormone
Biology
Epithelium
Human chorionic gonadotropin
Behavioral Neuroscience
Internal medicine
medicine
Humans
Child
Endocrine and Autonomic Systems
Infant, Newborn
Infant
Neurosecretory Systems
Hormones
Prolactin
Endocrinology
Somatostatin
Child, Preschool
Female
Corticotropic cell
Gonadotropin
Luteinizing hormone
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 08891591
- Volume :
- 6
- Database :
- OpenAIRE
- Journal :
- Brain, Behavior, and Immunity
- Accession number :
- edsair.doi.dedup.....cf746248dafd35788c782c5567f1ba65
- Full Text :
- https://doi.org/10.1016/0889-1591(92)90047-r