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Drug addiction is not an independent risk factor for oncogenic human papillomavirus infections or high-grade cervical intraepithelial neoplasia: case-control study nested within the Latin American Screening study cohort
- Source :
- Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP
- Publication Year :
- 2008
- Publisher :
- SAGE Publications, 2008.
-
Abstract
- Drug abuse (addiction) has been listed among the risk factors for human papillomavirus (HPV) infections, but no case-control studies exist to rule out sexual behaviour and other potential confounders. The aim of this study is to evaluate the role of drug addiction as an independent predictor of HR-HPV infections and (cervical intraepithelial neoplasia) CIN2+ in an age-matched case-control (1:4) study nested within the prospective Latin American Screening (LAMS) study cohort. All 109 women in the LAMS cohort (n=12,114) reporting drug abuse/addiction were matched with four controls (n = 436) of non-abusers strictly by age. Conditional logistic regression analysis was used to estimate the co-variates of drug abuse, and the whole series (n=545) was analysed for predictors of HR-HPV and CIN2+ using univariate and multivariate regression models. Oncogenic HPV infections were significantly (P=0.019) more prevalent among abusers (37.7%) than in controls (21.9%), but there was no difference in high-grade squamous intraepithelial lesions (P=0.180) or CIN2+ lesions (P=0.201). In multivariate conditional logistic regression, number of lifetime sexual partners (P=0.0001), ever smokers (P=0.0001), non-use of OCs (P=0.013), ever having sexually transmitted diseases (STD) (P=0.041) and no previous Pap smear (P=0.027) were independent co-variates of drug addiction. Drug abuse was not an independent risk factor of high-risk (HR)-HPV infection, which was significantly predicted by (1) age below 30 years (P=0.045), (2) more than five lifetime sexual partners (P=0.046) and (3) being current smoker (P=0.0001). In multivariate model, only HR-HPV infection was an independent risk factor of CIN2+ (P=0.031), with adjusted OR=11.33 (95% CI 1.25-102.50). These data indicate that drug addiction is not an independent risk factor of either HR-HPV infections or CIN2+, but the increased prevalence of HR-HPV infections is explained by the high-risk sexual behaviour and smoking habits of these women.<br />European Commission (LAMS denotes Latin American Screening study funded by European Commission), INCO-DEV Programme (Contract No. ICA4-CT-2001-10013). The generous contribution of DIGENE Inc. (USA) donating the HCII tests at our disposal is gratefully acknowledged
- Subjects :
- Sexually transmitted disease
Case-control setting
Medicina Básica [Ciências Médicas]
Cohort Studies
0302 clinical medicine
Pharmacology (medical)
030212 general & internal medicine
CIN
Cervical cancer
Smoking
Middle Aged
female genital diseases and pregnancy complications
3. Good health
Substance abuse
Infectious Diseases
030220 oncology & carcinogenesis
Ciências Médicas::Medicina Básica
Cohort
Female
Papanicolaou Test
Cohort study
Adult
medicine.medical_specialty
Adolescent
Substance-Related Disorders
Addiction
Dermatology
Cervical intraepithelial neoplasia
Drug abuse
03 medical and health sciences
Internal medicine
Conditional logistic regression
medicine
Humans
HR-HPV
Cervical Intraepithelial Neoplasia
Risk factor
Aged
Vaginal Smears
Gynecology
Science & Technology
business.industry
Papillomavirus Infections
Public Health, Environmental and Occupational Health
Uterine Cervical Dysplasia
medicine.disease
Risk factors
Case-Control Studies
High Grade Cervical Intraepithelial Neoplasia
business
Subjects
Details
- ISSN :
- 17581052 and 09564624
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- International Journal of STD & AIDS
- Accession number :
- edsair.doi.dedup.....cf8d10f6408c5850464bbbb2d20759aa