Back to Search
Start Over
Effects of intermittent hypoxia on cat petrosal ganglion responses induced by acetylcholine, adenosine 5′-triphosphate and NaCN
- Source :
- Brain Research. 1128:86-90
- Publication Year :
- 2007
- Publisher :
- Elsevier BV, 2007.
-
Abstract
- Exposure to chronic intermittent hypoxia (CIH) for 4 days enhances the cat carotid body (CB) chemosensory responses to acute hypoxia. However, it is not known if CIH enhances the responses of the petrosal ganglion (PG) neurons that innervate the CB chemoreceptor cells. Accordingly, we studied the effects of the CB putative excitatory transmitter acetylcholine (ACh) and adenosine 5´-triphosphate (ATP), and the effects of citotoxic hypoxia (NaCN) applied to the isolated PG from cats exposed to CIH for 4 days. The dose-dependent curve parameters of the frequency of discharges evoked in the carotid sinus nerve by the application of ACh, ATP and NaCN to the isolated PG in control condition were not significantly modified in the CIH-treated cats. Present results suggest that CIH enhances the chemosensory responses to acute hypoxia acting primarily at the chemoreceptor cells, without major changes in the response of PG neurons evoked by the application of putative CB excitatory transmitters to their somata.
- Subjects :
- medicine.medical_specialty
Chemoreceptor
Action Potentials
Biology
chemistry.chemical_compound
Adenosine Triphosphate
Ganglia, Sensory
Sodium Cyanide
Internal medicine
medicine
Animals
Hypoxia
Neurotransmitter
Molecular Biology
Glossopharyngeal Nerve
Analysis of Variance
Carotid Body
Dose-Response Relationship, Drug
General Neuroscience
Intermittent hypoxia
Hypoxia (medical)
Adenosine
Acetylcholine
medicine.anatomical_structure
Endocrinology
chemistry
Cats
Excitatory postsynaptic potential
Carotid body
Neurology (clinical)
medicine.symptom
Developmental Biology
medicine.drug
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 1128
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....cf96ce015bb8fa098b931673f1564c71