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The impact of pathogen burden on leukocyte telomere length in the Multi-Ethnic Study of Atherosclerosis
- Source :
- Epidemiol Infect
- Publication Year :
- 2017
-
Abstract
- SUMMARYSeveral infections have been linked to telomere shortening and in some cases these associations have varied by sex. We assessed the association between seropositivity to four persistent pathogens (cytomegalovirus (CMV), herpes simplex virus-1,Helicobacter pylori,Chlamydia pneumoniae), and total pathogen burden on leukocyte telomere length in a diverse US sample. Data came from the Multi-Ethnic Study of Atherosclerosis, a population-based cohort study. We utilized cross-sectional survey data, and biological samples from participants tested for pathogens and telomere length (N= 163). Linear regression was used to examine the association between seropositivity for individual pathogens as well as total pathogen burden and telomere length, adjusting for various confounders. CMV seropositivity and increased total pathogen burden level were significantly associated with shorter telomere length among females (β= −0·1204 (standard error (s.e.) 0·06),P= 0·044) and (β= −0·1057 (s.e.= 0·05),P= 0·033), respectively. There was no statistically significant association among males. Our findings suggest that prevention or treatment of persistent pathogens, in particular CMV, may play an important role in reducing telomere shortening over the life course among women. Future research is needed to confirm these novel findings in larger longitudinal samples.
- Subjects :
- 0301 basic medicine
Male
Epidemiology
Population
Cytomegalovirus
Herpesvirus 1, Human
medicine.disease_cause
Helicobacter Infections
03 medical and health sciences
0302 clinical medicine
Seroepidemiologic Studies
Leukocytes
Medicine
Humans
030212 general & internal medicine
Longitudinal Studies
education
Pathogen
Chlamydophila Infections
Telomere Shortening
Aged
Aged, 80 and over
education.field_of_study
Chlamydia
biology
Helicobacter pylori
business.industry
Confounding
Herpes Simplex
Chlamydophila pneumoniae
Middle Aged
Viral Load
medicine.disease
biology.organism_classification
Atherosclerosis
Original Papers
Bacterial Load
United States
Telomere
030104 developmental biology
Infectious Diseases
Herpes simplex virus
Immunology
Cytomegalovirus Infections
Female
business
Cohort study
Subjects
Details
- ISSN :
- 14694409
- Volume :
- 145
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- Epidemiology and infection
- Accession number :
- edsair.doi.dedup.....cfadd9ee8ae03db95d7e78e4a387c457