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Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia

Authors :
Mohammad Hojjat-Farsangi
Håkan Mellstedt
Anders Österborg
Lotta Hansson
Amir Hossein Daneshmanesh
Ali Moshfegh
Abdul Salam Khan
Parviz Kokhaei
Source :
Tumor Biology. 37:11947-11957
Publication Year :
2016
Publisher :
Springer Science and Business Media LLC, 2016.

Abstract

Dishevelled (DVL) proteins are components of the Wnt signalling pathways, and increased expression is associated with various malignancies. Information on DVLs in chronic lymphatic leukaemia (CLL) is limited. The aim of the present study was to investigate the role of DVLs in CLL cells and association with Wnt pathways downstream of ROR1. DVL1, 2 and 3 were exclusively expressed in CLL cells as compared to normal peripheral blood mononuclear cells (PBMCs). The expression of DVL1 and DVL3 proteins was significantly more pronounced in progressive than in non-progressive disease (p

Details

ISSN :
14230380 and 10104283
Volume :
37
Database :
OpenAIRE
Journal :
Tumor Biology
Accession number :
edsair.doi.dedup.....cfc57608b71706d95566affb771d4ab2
Full Text :
https://doi.org/10.1007/s13277-016-5039-5