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Major depressive disorder is associated with fragmented QRS
- Source :
- Acta Cardiologica. 72:156-160
- Publication Year :
- 2017
- Publisher :
- Informa UK Limited, 2017.
-
Abstract
- Objective There is a close link between major depressive disorder (MDD) and cardiovascular disease (CVD). Increasing oxidative stress, changes in hypothalamic-pituitary-adrenal axis and platelet clotting cascade may lead to subclinical myocardial damage in MDD patients without overt CVD. The aim of the study was to investigate whether MDD is associated with fragmented QRS (fQRS) on electrocardiogram (ECG) which may reflect myocardial fibrosis/scarring and ischaemia. Methods and results A total of 66 MDD patients without overt CVD and 35 age- and sex-matched control subjects were enrolled in this study. Twelve-lead surface ECGs were analysed for the presence of fQRS and echocardiographic examination was performed for each individual. Multivariate logistic regression analysis was used to assess the relationship between MDD and fQRS. The baseline characteristics in terms of age, gender, body mass index and cardiovascular risk factors were comparable in the groups (all P values0.05). Left ventricular ejection fraction, left ventricular wall thickness and diastolic blood pressure were also similar in the two groups. The presence of fQRS was more prevalent (P 0.001) and SBP values (P = 0.007) were higher in patients with MDD compared to controls. Moreover, multivariate binary logistic regression analysis indicated the recurrent MDD as the only independent predictor of fQRS on ECG (beta =0.196, 95% CI 0.046 - 0.827, P = 0.014). Conclusion The presence of fQRS on the ECG is associated with MDD, and may be a beneficial tool for detecting subclinical cardiac damage in this population.
- Subjects :
- Adult
Male
medicine.medical_specialty
Heart Ventricles
Fragmented qrs
Disease
030204 cardiovascular system & hematology
Logistic regression
Ventricular Function, Left
Electrocardiography
03 medical and health sciences
0302 clinical medicine
Recurrence
Internal medicine
Humans
Medicine
cardiovascular diseases
Psychiatry
Retrospective Studies
Subclinical infection
Depressive Disorder, Major
business.industry
General Medicine
Clotting cascade
medicine.disease
030227 psychiatry
Survival Rate
ROC Curve
Cardiovascular Diseases
Echocardiography
Cardiology
Major depressive disorder
Female
Myocardial fibrosis
Cardiology and Cardiovascular Medicine
business
Body mass index
Follow-Up Studies
Subjects
Details
- ISSN :
- 03737934 and 00015385
- Volume :
- 72
- Database :
- OpenAIRE
- Journal :
- Acta Cardiologica
- Accession number :
- edsair.doi.dedup.....cfcc9380103a585f360ffd5a75a229e9