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Amphetamine-induced release of diadenosine polyphosphates - Ap4A and Ap5A - from caudate putamen of conscious rat
- Source :
- Neuroscience Letters. 150:13-16
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- The release of diadenosine polyphosphates - diadenosine tetraphosphate (Ap 4 A) and diadenosine pentaphosphate (Ap 5 A) - was measured by intracerebral push-pull perfusion in conscious rats after systemic amphetamine injection. Samples were collected from the caudate putamen, and nucleotide compounds were analyzed by HPLC. The presence of Ap 4 A and Ap 5 A was demonstrated by their retention times and phosphodiesterase digestion. Dinucleotides were not detectable before amphetamine injection (5 mg/kg). The maximal levels were reached 20 min after the injection with values of 12.9 ± 0.9 and 11.5 ± 0.9 pmol/fraction for Ap 4 A and Ap 5 A, respectively. A slow and progressive decrease in their concentration followed. This study shows for the first time the amphetamine-induced release of diadenosine polyphosphates in conscious rats, and a role for Ap 4 A and Ap 5 A in the central nervous system is therefore suggested.
- Subjects :
- Male
medicine.medical_specialty
Central nervous system
chemistry.chemical_compound
Internal medicine
Basal ganglia
medicine
Animals
Nucleotide
Rats, Wistar
Amphetamine
Chromatography, High Pressure Liquid
chemistry.chemical_classification
Adenine Nucleotides
General Neuroscience
Putamen
Phosphodiesterase
Rats
Endocrinology
medicine.anatomical_structure
chemistry
Biochemistry
Liberation
Caudate Nucleus
Ap4A
Perfusion
Dinucleoside Phosphates
Injections, Intraperitoneal
medicine.drug
Subjects
Details
- ISSN :
- 03043940
- Volume :
- 150
- Database :
- OpenAIRE
- Journal :
- Neuroscience Letters
- Accession number :
- edsair.doi.dedup.....d00c5e457d6c0c1b5d86e52f4d7252b3