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Calcium/vitamin D supplementation and coronary artery calcification in the Women's Health Initiative
- Source :
- Menopause (New York, N.Y.). 17(4)
- Publication Year :
- 2010
-
Abstract
- Coronary artery calcified plaque is a marker for atheromatous plaque burden and predicts future risk of cardiovascular events. The relationship between calcium plus vitamin D (calcium/D) supplementation and coronary artery calcium (CAC) has not been previously assessed in a randomized trial setting. We compared CAC scores after trial completion between women randomized to calcium/vitamin D supplementation and women randomized to placebo.In an ancillary substudy of women randomized to calcium carbonate (1,000 mg of elemental calcium daily) plus vitamin D3 (400 IU daily) or placebo, nested within the Women's Health Initiative trial of estrogen among women who underwent hysterectomy, we measured CAC with cardiac CT in 754 women aged 50 to 59 years at randomization. Imaging for CAC was performed at 28 of 40 centers after a mean of 7 years of treatment, and scans were read centrally. CAC scores were measured by a central reading center with masking to randomization assignments.Posttrial CAC measurements were similar in women randomized to calcium/D supplementation and those receiving placebo. The mean CAC score was 91.6 for women receiving calcium/D and 100.5 for women receiving placebo (rank test P value = 0.74). After adjustment for coronary risk factors, multivariate odds ratios for increasing CAC score cutpoints (CAC0,or =10, andor =100) for calcium/D versus placebo were 0.92 (95% CI, 0.64-1.34), 1.29 (0.88-1.87), and 0.90 (0.56-1.44), respectively. Corresponding odds ratios among women with a 50% or higher adherence to study pills and for higher levels of CAC (300) were similar.Treatment with moderate doses of calcium plus vitamin D3 did not seem to alter coronary artery calcified plaque burden among postmenopausal women. Whether higher or lower doses would affect this outcome remains uncertain.
- Subjects :
- medicine.medical_specialty
chemistry.chemical_element
Coronary Artery Disease
Calcium
Coronary Angiography
law.invention
Calcium Carbonate
Coronary artery disease
chemistry.chemical_compound
Randomized controlled trial
Double-Blind Method
law
Calcinosis
Internal medicine
medicine
Vitamin D and neurology
Humans
Cholecalciferol
Bone Density Conservation Agents
business.industry
Women's Health Initiative
Obstetrics and Gynecology
Middle Aged
medicine.disease
Postmenopause
medicine.anatomical_structure
chemistry
Cardiology
Female
business
Tomography, X-Ray Computed
Artery
Subjects
Details
- ISSN :
- 15300374
- Volume :
- 17
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Menopause (New York, N.Y.)
- Accession number :
- edsair.doi.dedup.....d0217129e9163fb53b1bf4acb0caaf83