[1,2,4]Triazolo[3,4-b]benzothiazole scaffold as versatile nicotinamide mimic allowing nanomolar inhibition of different PARP enzymes

Authors :: Sudarshan Murthy
Maria Giulia Nizi
Mirko M. Maksimainen
Serena Massari
Juho Alaviuhkola
Barbara E. Lippok
Chiara Vagaggini
Sven T. Sowa
Albert Galera-Prat
Yashwanth Ashok
Harikanth Venkannagari
Renata Prunskaite-Hyyryläinen
Elena Dreassi
Bernhard Lüscher
Patricia Korn
Oriana Tabarrini
Lari Lehtiö
Source :: Journal of medicinal chemistry 66(2), 1301-1320 (2023). doi:10.1021/acs.jmedchem.2c01460
Publication Year :: 2023
Publisher :: American Chemical Society, 2023.
Abstract: Journal of medicinal chemistry 66(2), 1301-1320 (2023). doi:10.1021/acs.jmedchem.2c01460<br />Published by American Chemical Society, Washington, DC

Subjects :: Scaffolds
Inhibitors
Drug Discovery
Molecular Medicine
Reaction products
ddc:610
Peptides and proteins
Assays

Language :: English
Database :: OpenAIRE
Journal :: Journal of medicinal chemistry 66(2), 1301-1320 (2023). doi:10.1021/acs.jmedchem.2c01460
Accession number :: edsair.doi.dedup.....d02c78b88c3e04c15acc5405940609a1
Full Text :: https://doi.org/10.1021/acs.jmedchem.2c01460

Full Text Access

Tools