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Circulating Estrogen Levels and Self-Reported Health and Mobility Limitation in Community-Dwelling Men of the Framingham Heart Study
- Source :
- The journals of gerontology. Series A, Biological sciences and medical sciences. 72(8)
- Publication Year :
- 2015
-
Abstract
- Background Self-rated health is a commonly used global indicator of health status. Few studies have examined the association of self-rated health and mobility with estrone and estradiol in men. Accordingly, we determined the cross-sectional, incident, and mediating relations between circulating estrone and estradiol levels with self-rated health, mobility limitation, and physical performance in community-dwelling men. Methods The cross-sectional sample included 1,148 men, who attended Framingham Offspring Study Examinations 7 and 8. Estrone and estradiol levels were measured using liquid chromatography tandem mass spectrometry at Examination 7. Self-reported mobility limitation and self-rated health were assessed at Examinations 7 and 8. Additionally, short physical performance battery, usual walking speed, and grip strength were assessed at Examination 7. Results In incident analysis, estradiol levels at Examination 7 were associated with increased odds of fair or poor self-rated health at Examination 8, after adjusting for age, body mass index, comorbidities, and testosterone levels; in an individual with 50% greater estradiol than other, the odds of reporting "fair or poor" self-rated health increased by 1.78 (95% confidence interval: 1.25-2.55; p = .001). Neither estrone nor estradiol levels were associated with any physical performance measure at baseline. Conclusions Higher circulating levels of estradiol are associated with increased risk of incident fair/poor self-rated health in community-dwelling men. The mechanisms by which circulating levels of estradiol are related to self-rated health in men need further investigation.
- Subjects :
- Male
medicine.medical_specialty
Aging
Self-Assessment
medicine.drug_class
Estrone
Statistics as Topic
030209 endocrinology & metabolism
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Framingham Heart Study
Internal medicine
medicine
Humans
030212 general & internal medicine
Mobility Limitation
Geriatric Assessment
Testosterone
Self-rated health
Aged
Framingham Risk Score
Estradiol
Hand Strength
business.industry
Obstetrics
Health Status Disparities
Middle Aged
Confidence interval
United States
Walking Speed
Endocrinology
Cross-Sectional Studies
chemistry
Estrogen
Independent Living
Geriatrics and Gerontology
business
Body mass index
Research Article
Subjects
Details
- ISSN :
- 1758535X
- Volume :
- 72
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- The journals of gerontology. Series A, Biological sciences and medical sciences
- Accession number :
- edsair.doi.dedup.....d034a64ce4934ee3098ba81433582433