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Strain differences in the development of cisplatin-induced pica behavior in mice
- Source :
- Journal of Pharmacological and Toxicological Methods. 91:66-71
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Pica behavior, kaolin ingestion, in rats and mice can be used as an assessment of nausea and vomiting; however, we observed that the incidence of pica behavior in ICR strain mice varied markedly. We investigated the susceptibility of four strains of mice (ICR, BALB/c, C57BL/6, and DBA/2) to the development of pica behavior.Mice received cisplatin (7.5 mg/kg, i.p.) with or without a serotonin 5-HTAll mice except for ICR strain significantly increased kaolin intake after cisplatin administration. Among the tested strains, DBA/2 mice compared to BALB/c and C57BL/6 mice notably showed pica behavior on both days (P 0.0001). The expression of PPT-A mRNA was significantly increased 8 h after cisplatin administration in all strains, but the increase remained on the second day only in DBA/2 mice (P 0.05). Granisetron significantly inhibited pica behavior in DBA/2 mice on the first day (P 0.0001), but not the second day; however, fosaprepitant completely inhibited the pica behavior on both days (P 0.001).These results indicate that cisplatin-induced pica behavior in mice is likely to be influenced by the genotype, and that DBA/2 mice are useful to analyze the emetogenic or anti-emetic potential of drugs in preclinical studies.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Preprotachykinin
Vomiting
medicine.drug_class
Drug Evaluation, Preclinical
Antineoplastic Agents
Toxicology
Granisetron
Eating
Mice
03 medical and health sciences
0302 clinical medicine
Species Specificity
Internal medicine
medicine
Animals
Humans
Ingestion
Pica (disorder)
Kaolin
Pharmacology
Mice, Inbred BALB C
Mice, Inbred ICR
Behavior, Animal
business.industry
Incidence
Nausea
Receptor antagonist
Mice, Inbred C57BL
Disease Models, Animal
030104 developmental biology
Endocrinology
Mice, Inbred DBA
Pica
Antiemetics
NK1 receptor antagonist
Serotonin
Cisplatin
medicine.symptom
business
030217 neurology & neurosurgery
Chemotherapy-induced nausea and vomiting
medicine.drug
Subjects
Details
- ISSN :
- 10568719
- Volume :
- 91
- Database :
- OpenAIRE
- Journal :
- Journal of Pharmacological and Toxicological Methods
- Accession number :
- edsair.doi.dedup.....d037aa0e1e18be72c6f5816dafafd154